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Autophagy in healthy aging and disease
Autophagy is a fundamental cellular process that eliminates molecules and subcellular
elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated …
elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated …
Autophagy in metabolic disease and ageing
M Kitada, D Koya - Nature Reviews Endocrinology, 2021 - nature.com
Autophagy is an evolutionarily conserved, lysosome-dependent catabolic process whereby
cytoplasmic components, including damaged organelles, protein aggregates and lipid …
cytoplasmic components, including damaged organelles, protein aggregates and lipid …
Mechanisms of muscle atrophy and hypertrophy: implications in health and disease
R Sartori, V Romanello, M Sandri - Nature communications, 2021 - nature.com
Skeletal muscle is the protein reservoir of our body and an important regulator of glucose
and lipid homeostasis. Consequently, the growth or the loss of muscle mass can influence …
and lipid homeostasis. Consequently, the growth or the loss of muscle mass can influence …
[HTML][HTML] Physical activity and exercise: Strategies to manage frailty
J Angulo, M El Assar, A Álvarez-Bustos… - Redox biology, 2020 - Elsevier
Frailty, a consequence of the interaction of the aging process and certain chronic diseases,
compromises functional outcomes in the elderly and substantially increases their risk for …
compromises functional outcomes in the elderly and substantially increases their risk for …
[HTML][HTML] Sarcopenia–Molecular mechanisms and open questions
P Wiedmer, T Jung, JP Castro, LCD Pomatto… - Ageing research …, 2021 - Elsevier
Sarcopenia represents a muscle-wasting syndrome characterized by progressive and
generalized degenerative loss of skeletal muscle mass, quality, and strength occurring …
generalized degenerative loss of skeletal muscle mass, quality, and strength occurring …
Sarcopenia: aging-related loss of muscle mass and function
Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility,
diminishes quality of life, and can lead to fall-related injuries, which require costly …
diminishes quality of life, and can lead to fall-related injuries, which require costly …
Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies
The prevalence of obesity in combination with sarcopenia (the age-related loss of muscle
mass and strength or physical function) is increasing in adults aged 65 years and older. A …
mass and strength or physical function) is increasing in adults aged 65 years and older. A …
Autophagy as a promoter of longevity: insights from model organisms
Autophagy is a conserved process that catabolizes intracellular components to maintain
energy homeostasis and to protect cells against stress. Autophagy has crucial roles during …
energy homeostasis and to protect cells against stress. Autophagy has crucial roles during …
Health consequences of sarcopenic obesity: a narrative review
E Roh, KM Choi - Frontiers in endocrinology, 2020 - frontiersin.org
Sarcopenia is defined as the age-related loss of muscle mass and strength or physical
performance. Increased amounts of adipose tissue often accompany sarcopenia, a condition …
performance. Increased amounts of adipose tissue often accompany sarcopenia, a condition …
Autophagy and the cell biology of age-related disease
Macroautophagy (autophagy) is a conserved lysosomal degradation process essential for
cellular homeostasis and adaption to stress. Accumulating evidence indicates that …
cellular homeostasis and adaption to stress. Accumulating evidence indicates that …