Conspectus Over the last century, malaria deaths have decreased by more than 85%.
Nonetheless, there were 405 000 deaths in 2018, mostly resulting from Plasmodium …

Formation of malaria pigment or haemozoin is the major route of haem detoxification in the
malaria parasite Plasmodium falciparum as well as several other species of …

To ensure their survival in the human bloodstream, malaria parasites degrade up to 80% of
the host erythrocyte hemoglobin in an acidified digestive vacuole. Here, we combine …

Antimalarial drugs such as chloroquine are believed to act by inhibiting hemozoin formation
in the food vacuole of the malaria parasite. We have developed a new assay for measuring …

Haeme metabolism remains a vulnerable problem for the intraerythrocytic Plasmodium
which catabolises haemoglobin as a source of amino acids in an acidic, oxygen-rich …

The digestive vacuole of the malaria parasite Plasmodium falciparum is the site of
haemoglobin digestion and haem detoxification, and is the target of chloroquine and other …

This review on the interplay between malaria, antimalarial drugs, and hemozoin crystals is
directed, on one hand, to biologists and pharmaceutical chemists who wish to have a …

Digestion of hemoglobin in the food vacuole of the malaria parasite produces very high
quantities of redox active toxic free heme. Hemozoin (β-hematin) formation is a unique …

The recent literature on hemozoin/β-hematin formation is reviewed, with an emphasis on the
mechanism of its formation. Recent findings from unrelated organisms that produce …

The optimal outcome of a malaria infection is that parasitized cells are killed and degraded
without inducing significant pathology. Since much of the pathology of malaria infection can …