Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system
Angiogenesis, the growth of blood vessels, is a fundamental biological process that controls
embryonic development and is also involved in numerous life-threatening human diseases …
embryonic development and is also involved in numerous life-threatening human diseases …
Signaling and functions of angiopoietin-1 in vascular protection
NPJ Brindle, P Saharinen, K Alitalo - Circulation research, 2006 - Am Heart Assoc
Angiopoietin-1 (Ang1) has powerful vascular protective effects: suppressing plasma
leakage, inhibiting vascular inflammation, and preventing endothelial death. Preclinical …
leakage, inhibiting vascular inflammation, and preventing endothelial death. Preclinical …
Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche
F Arai, A Hirao, M Ohmura, H Sato, S Matsuoka… - Cell, 2004 - cell.com
The quiescent state is thought to be an indispensable property for the maintenance of
hematopoietic stem cells (HSCs). Interaction of HSCs with their particular …
hematopoietic stem cells (HSCs). Interaction of HSCs with their particular …
Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesisin a mouse model
A Taguchi, T Soma, H Tanaka, T Kanda… - The Journal of …, 2004 - Am Soc Clin Investig
Thrombo-occlusive cerebrovascular disease resulting in stroke and permanent neuronal
loss is an important cause of morbidity and mortality. Because of the unique properties of …
loss is an important cause of morbidity and mortality. Because of the unique properties of …
The role of the Angiopoietins in vascular morphogenesis
M Thomas, HG Augustin - Angiogenesis, 2009 - Springer
Abstracts The Angiopoietin/Tie system acts as a vascular specific ligand/receptor system to
control endothelial cell survival and vascular maturation. The Angiopoietin family includes …
control endothelial cell survival and vascular maturation. The Angiopoietin family includes …
Tie receptors and their angiopoietin ligands are context-dependent regulators of vascular remodeling
L Eklund, BR Olsen - Experimental cell research, 2006 - Elsevier
Angiopoietins are ligands of the Tie2 receptor that control angiogenic remodeling in a
context-dependent manner. Tie signaling is involved in multiple steps of the angiogenic …
context-dependent manner. Tie signaling is involved in multiple steps of the angiogenic …
Vulnerability of the develo** brain to hypoxic-ischemic damage: contribution of the cerebral vasculature to injury and repair?
AA Baburamani, CJ Ek, DW Walker… - Frontiers in …, 2012 - frontiersin.org
As clinicians attempt to understand the underlying reasons for the vulnerability of different
regions of the develo** brain to injury, it is apparent that little is known as to how hypoxia …
regions of the develo** brain to injury, it is apparent that little is known as to how hypoxia …
VEGF-induced BBB permeability is associated with an MMP-9 activity increase in cerebral ischemia: both effects decreased by Ang-1
S Valable, J Montaner, A Bellail… - Journal of Cerebral …, 2005 - journals.sagepub.com
After cerebral ischemia, angiogenesis, by supplying for the deficient perfusion, may be a
beneficial process for limiting neuronal death and promoting tissue repair. In this study, we …
beneficial process for limiting neuronal death and promoting tissue repair. In this study, we …
Angiopoietin: a TIE (d) balance in tumor angiogenesis
WSN Shim, IAW Ho, PEH Wong - Molecular Cancer Research, 2007 - AACR
Abstract Angiopoietins (ANG-1 and ANG-2) and their TIE-2 receptor tyrosine kinase have
wide-ranging effects on tumor malignancy that includes angiogenesis, inflammation, and …
wide-ranging effects on tumor malignancy that includes angiogenesis, inflammation, and …
Pericytes in the myovascular niche promote post-natal myofiber growth and satellite cell quiescence
E Kostallari, Y Baba-Amer, S Alonso-Martin… - …, 2015 - journals.biologists.com
The satellite cells, which serve as adult muscle stem cells, are both located beneath
myofiber basement membranes and closely associated with capillary endothelial cells. We …
myofiber basement membranes and closely associated with capillary endothelial cells. We …