Phenol-soluble modulins–critical determinants of staphylococcal virulence

GYC Cheung, HS Joo, SS Chatterjee… - FEMS microbiology …, 2014 - academic.oup.com
Phenol-soluble modulins (PSMs) are a recently discovered family of amphipathic, alpha-
helical peptides that have multiple roles in staphylococcal pathogenesis and contribute to a …

Virulence attributes of successful methicillin-resistant Staphylococcus aureus lineages

JH Jiang, DR Cameron, C Nethercott… - Clinical microbiology …, 2023 - Am Soc Microbiol
Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of severe and often
fatal infections. MRSA epidemics have occurred in waves, whereby a previously successful …

Staphylococcus aureus causes aberrant epidermal lipid composition and skin barrier dysfunction

J Kim, BE Kim, E Berdyshev, I Bronova, L Bin, J Bae… - Allergy, 2023 - Wiley Online Library
Background Staphylococcus (S) aureus colonization is known to cause skin barrier
disruption in atopic dermatitis (AD) patients. However, it has not been studied how S. aureus …

New mechanistic insights into purine biosynthesis with second messenger c-di-AMP in relation to biofilm-related persistent methicillin-resistant Staphylococcus aureus …

L Li, Y Li, F Zhu, AL Cheung, G Wang, G Bai… - Mbio, 2021 - Am Soc Microbiol
Persistent methicillin-resistant Staphylococcus aureus (MRSA) endovascular infections
represent a significant clinically challenging subset of invasive, life-threatening S. aureus …

Impact of Vancomycin on sarA-Mediated Biofilm Formation: Role in Persistent Endovascular Infections Due to Methicillin-Resistant Staphylococcus aureus

W Abdelhady, AS Bayer, K Seidl… - The Journal of …, 2014 - academic.oup.com
Background. Staphylococcus aureus is the most common cause of endovascular infections.
The staphylococcal accessory regulator A locus (sarA) is a major virulence determinant that …

Staphylococcus aureus Extracellular Adherence Protein Triggers TNFα Release, Promoting Attachment to Endothelial Cells via Protein A

AM Edwards, MG Bowden, EL Brown, M Laabei… - 2012 - journals.plos.org
Staphylococcus aureus is a leading cause of bacteraemia, which frequently results in
complications such as infective endocarditis, osteomyelitis and exit from the bloodstream to …

The Global Regulon sarA Regulates β-Lactam Antibiotic Resistance in Methicillin-Resistant Staphylococcus aureus In Vitro and in Endovascular Infections

L Li, A Cheung, AS Bayer, L Chen… - The Journal of …, 2016 - academic.oup.com
Background. The global regulator sarA modulates virulence of methicillin-resistant
Staphylococcus aureus (MRSA) via regulation of principal virulence factors (eg, adhesins …

Cinnamaldehyde targets SarA to enhance β‐lactam antibiotic activity against methicillin‐resistant Staphylococcus aureus

J Li, T Lu, Y Chu, Y Zhang, J Zhang, W Fu, J Sun, Y Liu… - Mlife, 2024 - Wiley Online Library
Methicillin‐resistant Staphylococcus aureus (MRSA) is a current global public health
problem due to its increasing resistance to the most recent antibiotic therapies. One critical …

The Stringent Response Contributes to Persistent Methicillin-Resistant Staphylococcus aureus Endovascular Infection Through the Purine Biosynthetic Pathway

L Li, AS Bayer, A Cheung, L Lu… - The Journal of …, 2020 - academic.oup.com
Persistent methicillin-resistant Staphylococcus aureus (MRSA) endovascular infections
represent a significant clinical-therapeutic challenge. Of particular concern is antibiotic …

Using In Vivo Assessment on Host Defense Peptide Mimicking Polymer-Modified Surfaces for Combating Implant Infections

Y Qian, S Deng, Z Lu, Y She, J **e, Z Cong… - ACS Applied Bio …, 2020 - ACS Publications
Infections have accounted for the majority of failures in implants over the past decades. Host
defense peptide mimicking polymers have been considered as one of the promising …