Knee osteoarthritis: a review of pathogenesis and state-of-the-art non-operative therapeutic considerations

D Primorac, V Molnar, E Rod, Ž Jeleč, F Čukelj… - Genes, 2020 - mdpi.com
Being the most common musculoskeletal progressive condition, osteoarthritis is an
interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) …

Overview of MMP-13 as a promising target for the treatment of osteoarthritis

Q Hu, M Ecker - International journal of molecular sciences, 2021 - mdpi.com
Osteoarthritis (OA) is a common degenerative disease characterized by the destruction of
articular cartilage and chronic inflammation of surrounding tissues. Matrix metalloproteinase …

[HTML][HTML] Osteoarthritis pain

H Yu, T Huang, WW Lu, L Tong, D Chen - International journal of …, 2022 - mdpi.com
Joint pain is the hallmark symptom of osteoarthritis (OA) and the main reason for patients to
seek medical assistance. OA pain greatly contributes to functional limitations of joints and …

Exosomes: roles and therapeutic potential in osteoarthritis

Z Ni, S Zhou, S Li, L Kuang, H Chen, X Luo, J Ouyang… - Bone research, 2020 - nature.com
Exosomes participate in many physiological and pathological processes by regulating cell–
cell communication, which are involved in numerous diseases, including osteoarthritis (OA) …

Biomechanics of chondrocytes and chondrons in healthy conditions and osteoarthritis: A review of the mechanical characterisations at the microscale

S Pettenuzzo, A Arduino, E Belluzzi, A Pozzuoli… - Biomedicines, 2023 - mdpi.com
Biomechanical studies are expanding across a variety of fields, from biomedicine to
biomedical engineering. From the molecular to the system level, mechanical stimuli are …

Erosive hand osteoarthritis: latest findings and outlook

M Favero, E Belluzzi, A Ortolan, M Lorenzin… - Nature Reviews …, 2022 - nature.com
Osteoarthritis (OA) most commonly affects knee joints, and the next most commonly affected
sites are the hands and hips. Three distinct hand OA phenotypes have been described …

Human cartilage biomechanics: experimental and theoretical approaches towards the identification of mechanical properties in healthy and osteoarthritic conditions

E Belluzzi, S Todros, A Pozzuoli, P Ruggieri… - Processes, 2023 - mdpi.com
Articular cartilage is a complex connective tissue with the fundamental functions of load
bearing, shock absorption and lubrication in joints. However, traumatic events, aging and …

Infrapatellar fat pad-synovial membrane anatomo-fuctional unit: microscopic basis for Piezo1/2 mechanosensors involvement in osteoarthritis pain

A Emmi, E Stocco, R Boscolo-Berto… - Frontiers in Cell and …, 2022 - frontiersin.org
The Infrapatellar Fat Pad (IFP) is a fibro-adipose tissue of the knee recently reconsidered as
part of a single anatomo-functional unit (AFU) together with the synovial membrane (SM) …

Pathophysiology of musculoskeletal pain: a narrative review

F Puntillo, M Giglio, A Paladini… - Therapeutic …, 2021 - journals.sagepub.com
Musculoskeletal pain (excluding bone cancer pain) affects more than 30% of the global
population and imposes an enormous burden on patients, families, and caregivers related to …

The role of fibrosis in osteoarthritis progression

YA Rim, JH Ju - Life, 2020 - mdpi.com
Osteoarthritis (OA) is a chronic degenerative joint disease where the main characteristics
include cartilage degeneration and synovial membrane inflammation. These changes in the …