Oxidative stress, inflammation and colorectal cancer: an overview
Colorectal cancer (CRC) represents the second leading cause of cancer-related deaths
worldwide. The pathogenesis of CRC is a complex multistep process. Among other factors …
worldwide. The pathogenesis of CRC is a complex multistep process. Among other factors …
An update of Nrf2 activators and inhibitors in cancer prevention/promotion
Abstract NF-E2-related factor 2 (Nrf2) protein is a basic-region leucine zipper transcription
factor that defends against endogenous or exogenous stressors. By inducing several …
factor that defends against endogenous or exogenous stressors. By inducing several …
Hydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock: a retrospective before-after study
PE Marik, V Khangoora, R Rivera, MH Hooper… - Chest, 2017 - Elsevier
Background The global burden of sepsis is estimated as 15 to 19 million cases annually,
with a mortality rate approaching 60% in low-income countries. Methods In this retrospective …
with a mortality rate approaching 60% in low-income countries. Methods In this retrospective …
[HTML][HTML] Crosstalk of toll-like receptors signaling and Nrf2 pathway for regulation of inflammation
S Mohan, D Gupta - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Inflammation as a second line of defense of innate immunity plays a crucial role in
eliminating invading pathogens (bacteria, viruses, fungi as well as other parasites). The …
eliminating invading pathogens (bacteria, viruses, fungi as well as other parasites). The …
Vitamin C for the treatment of sepsis: the scientific rationale
PE Marik - Pharmacology & therapeutics, 2018 - Elsevier
Most vertebrates can synthesize vitamin C with synthesis increasing during stress. Humans,
however, have lost the ability to synthesize vitamin C. Vitamin C is an important anti-oxidant …
however, have lost the ability to synthesize vitamin C. Vitamin C is an important anti-oxidant …
Hydrocortisone, ascorbic acid and thiamine (HAT therapy) for the treatment of sepsis. Focus on ascorbic acid
PE Marik - Nutrients, 2018 - mdpi.com
Sepsis is a devastating disease that carries an enormous toll in terms of human suffering
and lives lost. Over 100 novel pharmacologic agents that targeted specific molecules or …
and lives lost. Over 100 novel pharmacologic agents that targeted specific molecules or …
Mechanism of glycyrrhizin on ferroptosis during acute liver failure by inhibiting oxidative stress
YAO Wang, Q Chen, C Shi… - Molecular medicine …, 2019 - spandidos-publications.com
The present study aimed to investigate the anti‑ferroptosis effects of the HMGB1 inhibitor
glycyrrhizin (GLY). The present study used a cell and animal model of acute liver failure …
glycyrrhizin (GLY). The present study used a cell and animal model of acute liver failure …
[HTML][HTML] Immunotherapy in sepsis-brake or accelerate?
F Steinhagen, SV Schmidt, JC Schewe… - Pharmacology & …, 2020 - Elsevier
Sepsis, a life threating syndrome characterized by organ failure after infection, is the most
common cause of death in hospitalized patients. The treatment of sepsis is generally …
common cause of death in hospitalized patients. The treatment of sepsis is generally …
An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapy
The Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor regulating a
wide array of genes for antioxidant and detoxification enzymes in response to oxidative and …
wide array of genes for antioxidant and detoxification enzymes in response to oxidative and …
Astaxanthin exerts anti-inflammatory and antioxidant effects in macrophages in NRF2-dependent and independent manners
Although anti-inflammatory effects of astaxanthin (ASTX) have been suggested, the
underlying mechanisms have not been fully understood. Particularly, the modulatory action …
underlying mechanisms have not been fully understood. Particularly, the modulatory action …