Hierarchical materials from high information content macromolecular building blocks: construction, dynamic interventions, and prediction
Hierarchical materials that exhibit order over multiple length scales are ubiquitous in nature.
Because hierarchy gives rise to unique properties and functions, many have sought …
Because hierarchy gives rise to unique properties and functions, many have sought …
Peptide science: A “rule model” for new generations of peptidomimetics
Peptides have been heavily investigated for their biocompatible and bioactive properties.
Though a wide array of functionalities can be introduced by varying the amino acid …
Though a wide array of functionalities can be introduced by varying the amino acid …
Cis-trans isomerization of peptoid residues in the collagen triple-helix
R Qiu, X Li, K Huang, W Bai, D Zhou, G Li… - Nature …, 2023 - nature.com
Cis-peptide bonds are rare in proteins, and building blocks less favorable to the trans-
conformer have been considered destabilizing. Although proline tolerates the cis-conformer …
conformer have been considered destabilizing. Although proline tolerates the cis-conformer …
Hierarchical self-assembly pathways of peptoid helices and sheets
Peptoids (N-substituted glycines) are a class of tailorable synthetic peptidomic polymers.
Amphiphilic diblock peptoids have been engineered to assemble 2D crystalline lattices with …
Amphiphilic diblock peptoids have been engineered to assemble 2D crystalline lattices with …
Rational Design of Novel Biomimetic Sequence-Defined Polymers for Mineralization Applications
Silica biomineralization is a naturally occurring process, wherein organisms use proteins
and other biological structures to direct the formation of complex, hierarchical …
and other biological structures to direct the formation of complex, hierarchical …
Structural elucidation of a polypeptoid chain in a crystalline lattice reveals key morphology-directing role of the N-terminus
The ability to engineer synthetic polymers with the same structural precision as
biomacromolecules is crucial to enable the de novo design of robust nanomaterials with …
biomacromolecules is crucial to enable the de novo design of robust nanomaterials with …
Efficient sampling of high-dimensional free energy landscapes using adaptive reinforced dynamics
Enhanced sampling methods such as metadynamics and umbrella sampling have become
essential tools for exploring the configuration space of molecules and materials. At the same …
essential tools for exploring the configuration space of molecules and materials. At the same …
Development of a Systematic and Extensible Force Field for Peptoids (STEPs)
Peptoids (N-substituted glycines) are a class of biomimetic polymers that have attracted
significant attention due to their accessible synthesis and enzymatic and thermal stability …
significant attention due to their accessible synthesis and enzymatic and thermal stability …
MARTINI-compatible coarse-grained model for the mesoscale simulation of peptoids
Peptoids (poly-N-substituted glycines) are a class of synthetic polymers that are
regioisomers of peptides (poly-C-substituted glycines), in which the point of side-chain …
regioisomers of peptides (poly-C-substituted glycines), in which the point of side-chain …
Glutamate affects self-assembly, protein corona, and anti-4 T1 tumor effects of melittin/vitamin E-succinic acid-(glutamate) n nanoparticles
X **, H Wu, J Yu, Y Cao, L Zhang, Z Zhang… - Journal of Controlled …, 2024 - Elsevier
Melittin (M) has attracted increasing attention for its significant antitumor effects and various
immunomodulatory effects. However, various obstacles such as the short plasma half-life …
immunomodulatory effects. However, various obstacles such as the short plasma half-life …