Bioactive lipid mediators resulting from the metabolism of polyunsaturated fatty acids (PUFA)
are controlled by many pathways that regulate the levels of these mediators and maintain …

Inflammation and oxidative stress play major roles in healthy and pathological pregnancy.
Environmental exposure to chemical pollutants may adversely affect maternal and fetal …

Preeclampsia (PE) is a hypertensive disease that affects pregnant women after 20 weeks of
gestation. This disease is associated with an important risk of maternal and fetal mortality …

Recurrent pregnancy loss (RPL) affects around 2% of women of reproductive age. Primary
RPL is defined by≥ 2 pregnancy losses and no normal birth delivery. In secondary RPL, the …

Microsomal epoxide hydrolase/epoxide hydrolase 1 (mEH/EPHX1) works in conjunction
with cytochromes P450 to metabolize a variety of compounds, including xenobiotics …

Background The epoxyeicosatrienoic acids (EETs) have antihypertensive, anti-inflammatory,
and organ protective properties and their circulation levels are related to hypertension …

Background: This project aimed to investigate the role of two arachidonic acid metabolites
(14, 15-epoxyeicosatrienoic acid (14, 15-EET) and 15-hydroxyeicosateraenoic acid (15 …

Objective To investigate the spatial and temporal changes of soluble epoxide hydrolase
(sEH) in the human placenta throughout gestation and to study the effects of hypoxia …

Objective: Preeclampsia (PE) is a disease that characterized by hypertension and
proteinuria during pregnancy. Epoxyeicosatrienoic acids (EETs) are arachidonic acid …

Epoxide hydrolases (EHs) of the α/β hydrolase fold enzyme family hydrolyze epoxides to the
corresponding vicinal diols. In mammals, epoxides are mainly formed within the body …