Psychedelics are serotonin 2A receptor agonists that can lead to profound changes in
perception, cognition and mood. In this review, we focus on the basic neurobiology …

The mystical experience is a potential psychological mechanism to influence outcome in
psychedelic therapy. It includes features such as oceanic boundlessness, ego dissolution …

Anorexia nervosa (AN) is a deadly illness with no proven treatments to reverse core
symptoms and no medications approved by the US Food and Drug Administration. Novel …

Background: Despite an increasing body of research highlighting their efficacy to treat a
broad range of medical conditions, psychedelic drugs remain a controversial issue among …

Classic psychedelics, such as LSD, psilocybin, and the DMT-containing beverage
ayahuasca, show some potential to treat depression, anxiety, and addiction. Importantly …

Importance Major depressive disorder (MDD) is a substantial public health burden, but
current treatments have limited effectiveness and adherence. Recent evidence suggests that …

This paper provides a critical review of several possible mechanisms at different levels of
analysis underlying the effects and therapeutic potential of psychedelics. At the (1) …

Design Open-label Randomized Randomized, double-blind, placebo-controlled
Randomized, double-blind, placebo-controlled Randomized, double-blind, placebo …

NEW YORK TIMES BESTSELLER• A “brilliant [and] entrancing”(The Guardian) journey into
the hidden lives of fungi—the great connectors of the living world—and their astonishing and …

Objective: The authors provide an evidenced-based summary of the literature on the clinical
application of psychedelic drugs in psychiatric disorders. Methods: Searches of PubMed and …