[HTML][HTML] Emerging therapeutic strategies to overcome drug resistance in cancer cells

P Garg, J Malhotra, P Kulkarni, D Horne, R Salgia… - Cancers, 2024 - mdpi.com
Simple Summary This review explores the challenges of drug resistance in cancer treatment
and discusses innovative strategies to overcome them. Researchers aim to understand how …

Recent advances and future perspectives in the therapeutics of prostate cancer

GL Varaprasad, VK Gupta, K Prasad, E Kim… - … Hematology & Oncology, 2023 - Springer
Prostate cancer (PC) is one of the most common cancers in males and the fifth leading
reason of death. Age, ethnicity, family history, and genetic defects are major factors that …

The next frontier in immunotherapy: potential and challenges of CAR-macrophages

J Li, P Chen, W Ma - Experimental Hematology & Oncology, 2024 - Springer
Chimeric antigen receptor macrophage (CAR-MΦ) represents a significant advancement in
immunotherapy, especially for treating solid tumors where traditional CAR-T therapies face …

[HTML][HTML] Next-Generation immunotherapy: Advancing clinical applications in cancer treatment

P Garg, S Pareek, P Kulkarni, D Horne… - Journal of Clinical …, 2024 - mdpi.com
Next-generation immunotherapies have revolutionized cancer treatment, offering hope for
patients with hard-to-treat tumors. This review focuses on the clinical applications and …

[HTML][HTML] Cell surface GRP78-directed CAR-T cells are effective at treating human pancreatic cancer in preclinical models

Y Yuan, J Fan, D Liang, S Wang, X Luo, Y Zhu… - Translational …, 2024 - Elsevier
Pancreatic cancer is a highly lethal solid malignancy with limited treatment options. Chimeric
antigen receptor T (CAR-T) cell therapy has been successfully applied to treat hematological …

Neurological insights into brain-targeted cancer therapy and bioinspired microrobots

S Ghosh, R Bhaskar, R Mishra, MA Babu… - Drug Discovery …, 2024 - Elsevier
Highlights•Bioinspired microrobots offer innovative solutions for brain-targeted cancer
therapy.•These microrobots navigate the blood–brain barrier for precise drug delivery.• …

Comparison of seven CD19 CAR designs in engineering NK cells for enhancing anti‐tumour activity

Y Wang, J Li, Z Wang, Y Liu, T Wang, M Zhang… - Cell …, 2024 - Wiley Online Library
Chimeric antigen receptor‐natural killer (CAR‐NK) cell therapy is emerging as a promising
cancer treatment, with notable safety and source diversity benefits over CAR‐T cells. This …

Charting new paradigms for CAR-T cell therapy beyond current Achilles heels

Y Li, Z Hu, Y Li, X Wu - Frontiers in Immunology, 2024 - frontiersin.org
Chimeric antigen receptor-T (CAR-T) cell therapy has made remarkable strides in treating
hematological malignancies. However, the widespread adoption of CAR-T cell therapy is …

[HTML][HTML] Efficient combination of radiotherapy and CAR-T–a systematic review

W Szlasa, A Sztuder, A Kaczmar-Dybko… - Biomedicine & …, 2024 - Elsevier
Chimeric antigen receptor T (CAR-T) cell therapy, a groundbreaking immunotherapy.
However, it faces formidable challenges in treating solid tumors, grappling with issues like …