In humans, the cytosolic glutathione S-transferase (GST) family of proteins is encoded by 16
genes presented in seven different classes. GSTs exhibit remarkable structural similarity …

Early human life is considered a critical window of susceptibility to external exposures.
Infants are exposed to a multitude of environmental factors, collectively referred to as the …

While whole animal studies have their place in risk assessment of food and feed
components, it is thought that more modern approaches such as human focused new …

This chapter introduces xenobiotic metabolism (in this chapter, the terms “xenobiotic
metabolism” and “xenobiotic-metabolizing enzyme” will be used in preference to “drug …

Abstract Low-molecular-weight (LMW) thiols are produced in all living cells in different forms
and concentrations. Glutathione (GSH), coenzyme A (CoASH), bacillithiol (BSH), mycothiol …

Bacterial cellulose (BC) is a promising natural polymer prized for its biocompatibility,
microporosity, transparency, conformability, elasticity, and ability to maintain a moist wound …

Addressing inter-and intra-species differences in potential hazardous effects of chemicals
remains a long-standing challenge in human health risk assessment that is typically …

Carboxylesterases (CES) are an important class of enzymes involved in the hydrolysis of a
range of chemicals and show large inter-individual variability in vitro. An extensive literature …

Epidemiological and mechanistic studies suggest that processed and red meat consumption
and tobacco smoking are associated with colorectal cancer (CRC) risk. Several classes of …

This external scientific report summarises the results from thearticle 36 grant
GA/EFSA/SCER/2015/01 ″Modelling human variability in toxicokinetic and toxicodynamic …