The current understanding of neurological diseases is derived mostly from direct analysis of
patients and from animal models of disease. However, most patient studies do not capture …

Abstract Hereditary Spastic Paraplegias (HSPs) are a heterogeneous group of disease,
mainly characterized by progressive spasticity and weakness of the lower limbs resulting …

Abstract 3D laboratory tissue cultures have emerged as an alternative to traditional 2D
culture systems that do not recapitulate native cell behavior. The discrepancy between in …

Region specific brain organoids are brain organoids derived by patterning protocols using
extrinsic signals as opposed to cerebral organoids obtained by self-patterning. The main …

Neurological disorders are challenging to study given the complexity and species-specific
features of the organ system. Brain organoids are three dimensional structured aggregates …

Hereditary spastic paraplegia (HSP) refers to a group of neurological disorders involving the
degeneration of motor neurons. Due to their clinical and genetic heterogeneity, finding …

Hereditary spastic paraplegias (HSP) are a group of neurodegenerative diseases sharing
spasticity in lower limbs as common symptom. There is a large clinical variability in the …

Hereditary spastic paraplegias (HSPs) comprise a family of degenerative diseases mostly
hitting descending axons of corticospinal neurons. Depending on the gene and mutation …

Simple Summary This review article describes an overview of the developed advanced
neural in vitro systems and the discovery of brain organoids including the recently …

Hereditary spastic paraplegia (HSP) is a heterogeneous group of rare motor neuron
disorders characterized by progressive weakness and spasticity of the lower limbs. HSP …