The impact of systemic inflammation on Alzheimer's disease pathology
Alzheimer's disease (AD) is a devastating age-related neurodegenerative disorder with an
alarming increasing prevalence. Except for the recently FDA-approved Aducanumab of …
alarming increasing prevalence. Except for the recently FDA-approved Aducanumab of …
Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination
Background The dietary consumption of cuprizone–a copper chelator–has long been known
to induce demyelination of specific brain structures and is widely used as model of multiple …
to induce demyelination of specific brain structures and is widely used as model of multiple …
Cerebrospinal fluid proteomics in patients with Alzheimer's disease reveals five molecular subtypes with distinct genetic risk profiles
Alzheimer's disease (AD) is heterogenous at the molecular level. Understanding this
heterogeneity is critical for AD drug development. Here we define AD molecular subtypes …
heterogeneity is critical for AD drug development. Here we define AD molecular subtypes …
Emerging roles for CNS fibroblasts in health, injury and disease
CE Dorrier, HE Jones, L Pintarić… - Nature Reviews …, 2022 - nature.com
Recent transcriptomic, histological and functional studies have begun to shine light on the
fibroblasts present in the meninges, choroid plexus and perivascular spaces of the brain and …
fibroblasts present in the meninges, choroid plexus and perivascular spaces of the brain and …
Human CNS barrier-forming organoids with cerebrospinal fluid production
INTRODUCTION The choroid plexus is a secretory epithelial tissue of the central nervous
system (CNS) responsible for cerebrospinal fluid (CSF) production and functions as a barrier …
system (CNS) responsible for cerebrospinal fluid (CSF) production and functions as a barrier …
Macrophages at CNS interfaces: ontogeny and function in health and disease
The segregation and limited regenerative capacity of the CNS necessitate a specialized and
tightly regulated resident immune system that continuously guards the CNS against invading …
tightly regulated resident immune system that continuously guards the CNS against invading …
Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype
The autophagy-lysosome pathway (ALP) regulates intracellular homeostasis of the cytosolic
protein SNCA/alpha-synuclein and is impaired in synucleinopathies, including Parkinson …
protein SNCA/alpha-synuclein and is impaired in synucleinopathies, including Parkinson …
Fluid and ion transfer across the blood–brain and blood–cerebrospinal fluid barriers; a comparative account of mechanisms and roles
SB Hladky, MA Barrand - Fluids and Barriers of the CNS, 2016 - Springer
The two major interfaces separating brain and blood have different primary roles. The
choroid plexuses secrete cerebrospinal fluid into the ventricles, accounting for most net fluid …
choroid plexuses secrete cerebrospinal fluid into the ventricles, accounting for most net fluid …
Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood–brain barrier
SB Hladky, MA Barrand - Fluids and Barriers of the CNS, 2018 - Springer
This review considers efflux of substances from brain parenchyma quantified as values of
clearances (CL, stated in µL g− 1 min− 1). Total clearance of a substance is the sum of …
clearances (CL, stated in µL g− 1 min− 1). Total clearance of a substance is the sum of …
Structure and junctional complexes of endothelial, epithelial and glial brain barriers
M Castro Dias, JA Mapunda, M Vladymyrov… - International journal of …, 2019 - mdpi.com
The homeostasis of the central nervous system (CNS) is ensured by the endothelial,
epithelial, mesothelial and glial brain barriers, which strictly control the passage of …
epithelial, mesothelial and glial brain barriers, which strictly control the passage of …