Acinetobacter baumannii Antibiotic Resistance Mechanisms

I Kyriakidis, E Vasileiou, ZD Pana, A Tragiannidis - Pathogens, 2021 - mdpi.com
Acinetobacter baumannii is a Gram-negative ESKAPE microorganism that poses a threat to
public health by causing severe and invasive (mostly nosocomial) infections linked with high …

Multidrug-resistant Acinetobacter baumannii as an emerging concern in hospitals

S Ibrahim, N Al-Saryi, IMS Al-Kadmy, SN Aziz - Molecular biology reports, 2021 - Springer
Acinetobacter baumannii has become a major concern for scientific attention due to
extensive antimicrobial resistance. This resistance causes an increase in mortality rate …

Antibiotic adjuvants: a versatile approach to combat antibiotic resistance

G Dhanda, Y Acharya, J Haldar - ACS omega, 2023 - ACS Publications
The problem of antibiotic resistance is on the rise, with multidrug-resistant strains emerging
even to the last resort antibiotics. The drug discovery process is often stalled by stringent cut …

Metallo-β-lactamases in the age of multidrug resistance: from structure and mechanism to evolution, dissemination, and inhibitor design

G Bahr, LJ Gonzalez, AJ Vila - Chemical reviews, 2021 - ACS Publications
Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

Interplay between β-lactamases and new β-lactamase inhibitors

K Bush, PA Bradford - Nature Reviews Microbiology, 2019 - nature.com
Resistance to β-lactam antibiotics in Gram-negative bacteria is commonly associated with
production of β-lactamases, including extended-spectrum β-lactamases (ESBLs) and …

Emergence, molecular mechanisms and global spread of carbapenem-resistant Acinetobacter baumannii

M Hamidian, SJ Nigro - Microbial genomics, 2019 - microbiologyresearch.org
Acinetobacter baumannii is a nosocomial pathogen that has emerged as a global threat
because of high levels of resistance to many antibiotics, particularly those considered to be …

The epidemiology of carbapenem-resistant Enterobacteriaceae: the impact and evolution of a global menace

LK Logan, RA Weinstein - The Journal of infectious diseases, 2017 - academic.oup.com
Carbapenem-resistant Enterobacteriaceae (CRE) are a serious public health threat.
Infections due to these organisms are associated with significant morbidity and mortality …

OXA-48-like β-lactamases: global epidemiology, treatment options, and development pipeline

SE Boyd, A Holmes, R Peck… - Antimicrobial agents …, 2022 - journals.asm.org
Modern medicine is threatened by the rising tide of antimicrobial resistance, especially
among Gram-negative bacteria, where resistance to β-lactams is most often mediated by β …

The global ascendency of OXA-48-type carbapenemases

JDD Pitout, G Peirano, MM Kock… - Clinical microbiology …, 2019 - journals.asm.org
Surveillance studies have shown that OXA-48-like carbapenemases are the most common
carbapenemases in Enterobacterales in certain regions of the world and are being …

[HTML][HTML] Epidemiology and mechanisms of resistance of extensively drug resistant Gram-negative bacteria

EM Eichenberger, JT Thaden - Antibiotics, 2019 - mdpi.com
Antibiotic resistance has increased markedly in gram-negative bacteria over the last two
decades, and in many cases has been associated with increased mortality and healthcare …