The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …

Adult cardiomyocytes are postmitotic cells that undergo very limited cell division. Thus,
cardiomyocyte death as occurs during myocardial infarction has very detrimental …

Mitochondria take up Ca2+ through the mitochondrial calcium uniporter complex to regulate
energy production, cytosolic Ca2+ signalling and cell death,. In mammals, the uniporter …

MICU1 is a calcium (Ca2+)–binding protein that regulates the mitochondrial Ca2+ uniporter
channel complex (mtCU) and mitochondrial Ca2+ uptake. MICU1 knockout mice display …

Abstract Mitochondrial calcium (Ca2+) signals play a central role in cardiac homeostasis
and disease. In the healthy heart, mitochondrial Ca2+ levels modulate the rate of oxidative …

Calcium ions are highly versatile intracellular signals that regulate many cellular processes.
The key to achieving this pleiotropic role is the spatiotemporal control of calcium …

Ferroptosis is an iron-and reactive oxygen species (ROS)-dependent form of regulated cell
death, that has been implicated in Alzheimer's disease and Parkinson's disease. Inhibition of …

Abstract Calcium (Ca 2+) signaling is critical for cell function and cell survival. Mitochondria
play a major role in regulating the intracellular Ca 2+ concentration ([Ca 2+] i). Mitochondrial …

Mitochondria are among the most important cell organelles involved in the regulation of
intracellular calcium homeostasis. During the last decade, a number of molecular structures …

Background: The mitochondrial calcium uniporter (mtCU) is an≈ 700-kD multisubunit
channel residing in the inner mitochondrial membrane required for mitochondrial Ca2+ …