New insights into activation and function of the AMPK
The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …
AMPK and TOR: the yin and yang of cellular nutrient sensing and growth control
The AMPK (AMP-activated protein kinase) and TOR (target-of-rapamycin) pathways are
interlinked, opposing signaling pathways involved in sensing availability of nutrients and …
interlinked, opposing signaling pathways involved in sensing availability of nutrients and …
AMPK: restoring metabolic homeostasis over space and time
E Trefts, RJ Shaw - Molecular cell, 2021 - cell.com
The evolution of AMPK and its homologs enabled exquisite responsivity and control of
cellular energetic homeostasis. Recent work has been critical in establishing the …
cellular energetic homeostasis. Recent work has been critical in establishing the …
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
One of the central regulators of cellular and organismal metabolism in eukaryotes is AMP-
activated protein kinase (AMPK), which is activated when intracellular ATP production …
activated protein kinase (AMPK), which is activated when intracellular ATP production …
ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions
Conserved signaling pathways that activate the mitogen-activated protein kinases (MAPKs)
are involved in relaying extracellular stimulations to intracellular responses. The MAPKs …
are involved in relaying extracellular stimulations to intracellular responses. The MAPKs …
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism
The AMP-activated protein kinase (AMPK) is an evolutionarily conserved sensor of cellular
energy status, and recent data demonstrate that it also plays a critical role in systemic …
energy status, and recent data demonstrate that it also plays a critical role in systemic …
AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function
DG Hardie - Genes & development, 2011 - genesdev.cshlp.org
AMP-activated protein kinase (AMPK) is a sensor of energy status that maintains cellular
energy homeostasis. It arose very early during eukaryotic evolution, and its ancestral role …
energy homeostasis. It arose very early during eukaryotic evolution, and its ancestral role …
Metformin and reduced risk of cancer in diabetic patients
Metformin, widely given to patients with type 2 diabetes, works by targeting the enzyme
AMPK (AMP activated protein kinase), which induces muscles to take up glucose from the …
AMPK (AMP activated protein kinase), which induces muscles to take up glucose from the …
[HTML][HTML] A tissue-specific atlas of mouse protein phosphorylation and expression
Although most tissues in an organism are genetically identical, the biochemistry of each is
optimized to fulfill its unique physiological roles, with important consequences for human …
optimized to fulfill its unique physiological roles, with important consequences for human …
The LKB1–AMPK pathway: metabolism and growth control in tumour suppression
DB Shackelford, RJ Shaw - Nature Reviews Cancer, 2009 - nature.com
In the past decade, studies of the human tumour suppressor LKB1 have uncovered a novel
signalling pathway that links cell metabolism to growth control and cell polarity. LKB1 …
signalling pathway that links cell metabolism to growth control and cell polarity. LKB1 …