DNA methylation is the most well studied of the epigenetic regulators in relation to
environmental exposures. To date, numerous studies have detailed the manner by which …

Obesity is a global health challenge that has received increasing attention in contemporary
research. The gut microbiota has been implicated in the development of obesity, primarily …

One carbon metabolism (OCM) is critical for early development, as it provides one carbon
(1C) units for the biosynthesis of DNA, proteins, and lipids and epigenetic modification of the …

The fetal origins of health and disease framework has identified extremes in fetal growth and
birth weight as factors associated with the lifelong generation of chronic diseases such as …

BACKGROUND Genomic imprinting is an epigenetic gene regulatory mechanism; disruption
of this process during early embryonic development can have major consequences on both …

Over the past decades, DNA methylation has been proposed as a molecular mechanism
underlying the positive or negative effects of diet on human health. Despite the number of …

Recent investigations have revealed that changes in DNA methylation status play an
important role in aging-associated pathologies and lifespan. The methylation of DNA is …

Background Gestational diabetes mellitus (GDM), characterized by hyperglycemia that
develops during pregnancy, increases the risk of fetal macrosomia, childhood obesity and …

As the very low-calorie ketogenic diet (VLCKD) gains increased interest as a therapeutic
approach for many diseases, little is known about its therapeutic use in childhood obesity …

Folate is a B-vitamin with an important role in health and disease. The optimal folate status
with regard to human health remains controversial. A low intake of natural folate as well as …