The landscape of aging
Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …
Macrophage related chronic inflammation in non-healing wounds
M Li, Q Hou, L Zhong, Y Zhao, X Fu - Frontiers in Immunology, 2021 - frontiersin.org
Persistent hyper-inflammation is a distinguishing pathophysiological characteristic of chronic
wounds, and macrophage malfunction is considered as a major contributor thereof. In this …
wounds, and macrophage malfunction is considered as a major contributor thereof. In this …
Therapeutic strategy of mesenchymal-stem-cell-derived extracellular vesicles as regenerative medicine
Y Matsuzaka, R Yashiro - International Journal of Molecular Sciences, 2022 - mdpi.com
Extracellular vesicles (EVs) are lipid bilayer membrane particles that play critical roles in
intracellular communication through EV-encapsulated informative content, including …
intracellular communication through EV-encapsulated informative content, including …
Sedentary behavior and the biological hallmarks of aging
While the benefits of physical exercise for a healthy aging are well-recognized, a growing
body of evidence shows that sedentary behavior has deleterious health effects …
body of evidence shows that sedentary behavior has deleterious health effects …
Targeting the stem cell niche micro-environment as therapeutic strategies in aging
Adult stem cells (ASCs) reside throughout the body and support various tissue. Owing to
their self-renewal capacity and differentiation potential, ASCs have the potential to be used …
their self-renewal capacity and differentiation potential, ASCs have the potential to be used …
[HTML][HTML] Epigenetic reprogramming as a key to reverse ageing and increase longevity
The pursuit for the fountain of youth has long been a fascination amongst scientists and
humanity. Ageing is broadly characterized by a cellular decline with increased susceptibility …
humanity. Ageing is broadly characterized by a cellular decline with increased susceptibility …
Retrotransposons as a Source of DNA Damage in Neurodegeneration
E Peze-Heidsieck, T Bonnifet, R Znaidi… - Frontiers in aging …, 2022 - frontiersin.org
The etiology of aging-associated neurodegenerative diseases (NDs), such as Parkinson's
disease (PD) and Alzheimer's disease (AD), still remains elusive and no curative treatment …
disease (PD) and Alzheimer's disease (AD), still remains elusive and no curative treatment …
The universal stem cell
PJ Quesenberry, S Wen, LR Goldberg, MS Dooner - Leukemia, 2022 - nature.com
Current dogma is that there exists a hematopoietic pluripotent stem cell, resident in the
marrow, which is quiescent, but with tremendous proliferative and differentiative potential …
marrow, which is quiescent, but with tremendous proliferative and differentiative potential …
Age-related changes in the fibroblastic differon of the dermis: role in skin aging
Skin aging is a multi-factorial process that affects nearly every aspect of skin biology and
function. The processes develo** in the skin during aging are based on fundamental …
function. The processes develo** in the skin during aging are based on fundamental …
Autophagy and polyphenol intervention strategy in aging
Y Gu, J Han - Trends in Food Science & Technology, 2023 - Elsevier
Background Aging refers to a comprehensive manifestation of decreased functions and
physical disorders during the degenerative period. Autophagy can remove damaged …
physical disorders during the degenerative period. Autophagy can remove damaged …