The landscape of aging

Y Cai, W Song, J Li, Y **g, C Liang, L Zhang… - Science China Life …, 2022 - Springer
Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Macrophage related chronic inflammation in non-healing wounds

M Li, Q Hou, L Zhong, Y Zhao, X Fu - Frontiers in Immunology, 2021 - frontiersin.org
Persistent hyper-inflammation is a distinguishing pathophysiological characteristic of chronic
wounds, and macrophage malfunction is considered as a major contributor thereof. In this …

Therapeutic strategy of mesenchymal-stem-cell-derived extracellular vesicles as regenerative medicine

Y Matsuzaka, R Yashiro - International Journal of Molecular Sciences, 2022 - mdpi.com
Extracellular vesicles (EVs) are lipid bilayer membrane particles that play critical roles in
intracellular communication through EV-encapsulated informative content, including …

Sedentary behavior and the biological hallmarks of aging

J Raffin, P de Souto Barreto, AP Le Traon… - Ageing Research …, 2023 - Elsevier
While the benefits of physical exercise for a healthy aging are well-recognized, a growing
body of evidence shows that sedentary behavior has deleterious health effects …

Targeting the stem cell niche micro-environment as therapeutic strategies in aging

R Farahzadi, B Valipour, S Montazersaheb… - Frontiers in Cell and …, 2023 - frontiersin.org
Adult stem cells (ASCs) reside throughout the body and support various tissue. Owing to
their self-renewal capacity and differentiation potential, ASCs have the potential to be used …

[HTML][HTML] Epigenetic reprogramming as a key to reverse ageing and increase longevity

B Pereira, FP Correia, IA Alves, M Costa… - Ageing research …, 2024 - Elsevier
The pursuit for the fountain of youth has long been a fascination amongst scientists and
humanity. Ageing is broadly characterized by a cellular decline with increased susceptibility …

Retrotransposons as a Source of DNA Damage in Neurodegeneration

E Peze-Heidsieck, T Bonnifet, R Znaidi… - Frontiers in aging …, 2022 - frontiersin.org
The etiology of aging-associated neurodegenerative diseases (NDs), such as Parkinson's
disease (PD) and Alzheimer's disease (AD), still remains elusive and no curative treatment …

The universal stem cell

PJ Quesenberry, S Wen, LR Goldberg, MS Dooner - Leukemia, 2022 - nature.com
Current dogma is that there exists a hematopoietic pluripotent stem cell, resident in the
marrow, which is quiescent, but with tremendous proliferative and differentiative potential …

Age-related changes in the fibroblastic differon of the dermis: role in skin aging

A Zorina, V Zorin, D Kudlay, P Kopnin - International Journal of Molecular …, 2022 - mdpi.com
Skin aging is a multi-factorial process that affects nearly every aspect of skin biology and
function. The processes develo** in the skin during aging are based on fundamental …

Autophagy and polyphenol intervention strategy in aging

Y Gu, J Han - Trends in Food Science & Technology, 2023 - Elsevier
Background Aging refers to a comprehensive manifestation of decreased functions and
physical disorders during the degenerative period. Autophagy can remove damaged …