Antimicrobial peptides targeting gram-positive bacteria

N Malanovic, K Lohner - Pharmaceuticals, 2016 - mdpi.com
Antimicrobial peptides (AMPs) have remarkably different structures as well as biological
activity profiles, whereupon most of these peptides are supposed to kill bacteria via …

Role of lipids in the interaction of antimicrobial peptides with membranes

V Teixeira, MJ Feio, M Bastos - Progress in lipid research, 2012 - Elsevier
Antimicrobial peptides (AMPs) take part in the immune system by mounting a first line of
defense against pathogens. Recurrent structural and functional aspects are observed …

[HTML][HTML] Membrane-active host defense peptides–challenges and perspectives for the development of novel anticancer drugs

S Riedl, D Zweytick, K Lohner - Chemistry and physics of lipids, 2011 - Elsevier
Although much progress has been achieved in the development of cancer therapies in
recent decades, problems continue to arise particularly with respect to chemotherapy due to …

[HTML][HTML] Arginine-rich cell-penetrating peptides

N Schmidt, A Mishra, GH Lai, GCL Wong - FEBS letters, 2010 - Elsevier
Arginine-rich cell-penetrating peptides are short cationic peptides capable of traversing the
plasma membranes of eukaryotic cells. While successful intracellular delivery of many …

Infectious disease: Connecting innate immunity to biocidal polymers

GJ Gabriel, A Som, AE Madkour, T Eren… - Materials Science and …, 2007 - Elsevier
Infectious disease is a critically important global healthcare issue. In the US alone there are
2 million new cases of hospital-acquired infections annually leading to 90,000 deaths and 5 …

Mechanism of the lamellar/inverse hexagonal phase transition examined by high resolution x-ray diffraction

M Rappolt, A Hickel, F Bringezu, K Lohner - Biophysical journal, 2003 - cell.com
For the first time the electron density of the lamellar liquid crystalline as well as of the
inverted hexagonal phase could be retrieved at the transition temperature. A reliable …

New strategies for novel antibiotics: peptides targeting bacterial cell membranes.

K Lohner - General physiology and biophysics, 2009 - europepmc.org
Membranes are targets of host defence or antimicrobial peptides, effector molecules of
innate immunity that evolved in nature to contend with invaders as an active system of …

Molecular mechanisms of membrane perturbation by antimicrobial peptides and the use of biophysical studies in the design of novel peptide antibiotics

K Lohner, SE Blondelle - Combinatorial chemistry & high …, 2005 - benthamdirect.com
Antibiotic resistant bacterial strains represent a global health problem with a strong social
and economic impact. Thus, there is an urgent need for the development of antibiotics with …

[HTML][HTML] Peptide induced demixing in PG/PE lipid mixtures: a mechanism for the specificity of antimicrobial peptides towards bacterial membranes?

A Arouri, M Dathe, A Blume - Biochimica et Biophysica Acta (BBA) …, 2009 - Elsevier
Antimicrobial peptides attract a lot of interest as potential candidates to overcome bacterial
resistance. So far, nearly all the proposed scenarios for their mechanism of action are …

[HTML][HTML] The role of spontaneous lipid curvature in the interaction of interfacially active peptides with membranes

D Koller, K Lohner - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2014 - Elsevier
Research on antimicrobial peptides is in part driven by urgent medical needs such as the
steady increase in pathogens being resistant to antibiotics. Despite the wealth of information …