Arousal may be understood on a spectrum, with excessive sleepiness, cognitive dysfunction,
and inattention on one side, a wakeful state in the middle, and hypervigilance, panic, and …

The physiological stress response is responsible for the maintenance of homeostasis in the
presence of real or perceived challenges. In this function, the brain activates adaptive …

Meta-analyses of genome-wide association studies (meta-GWASs) and candidate gene
studies have identified genetic variants associated with cardiovascular diseases, metabolic …

The neurohypophysial hormone arginine vasopressin (AVP) is essential for a wide range of
physiological functions, including water reabsorption, cardiovascular homeostasis, hormone …

Depression is one of the most prevalent forms of mental disorders and is the most common
cause of disability in the Western world. Besides, the harmful effects of stress-related mood …

Dysregulation of the corticotropin-releasing factor (CRF)–urocortin (UCN) system has been
implicated in stress-related psychopathologies such as depression and anxiety. It has been …

A concatenation of findings from preclinical and clinical studies support a preeminent
function for the corticotropin-releasing factor (CRF) system in mediating the physiological …

Stress is associated with the onset of several stress-related mental disorders that occur more
frequently in women than in men, such as major depression or posttraumatic stress disorder …

Corticotropin-releasing hormone (CRH) is a central integrator in the brain of endocrine and
behavioral stress responses, whereas activation of the endocannabinoid CB1 receptor …

Over the past few decades, corticotropin-releasing factor (CRF) signaling pathways have
been shown to be the main coordinators of the endocrine, behavioral, and immune …