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[HTML][HTML] Bioavailability enhancement techniques for poorly aqueous soluble drugs and therapeutics
The low water solubility of pharmacoactive molecules limits their pharmacological potential,
but the solubility parameter cannot compromise, and so different approaches are employed …
but the solubility parameter cannot compromise, and so different approaches are employed …
Pharmaceutical dispersion techniques for dissolution and bioavailability enhancement of poorly water-soluble drugs
Over the past decades, a large number of drugs as well as drug candidates with poor
dissolution characteristics have been witnessed, which invokes great interest in enabling …
dissolution characteristics have been witnessed, which invokes great interest in enabling …
[HTML][HTML] The potential use of simvastatin for cancer treatment: A review
JA Duarte, ALB de Barros, EA Leite - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Statins, typically used to reduce lipid levels, have been rediscovered for exhibiting
anticancer activities. Among them, especially simvastatin may influence the proliferation …
anticancer activities. Among them, especially simvastatin may influence the proliferation …
Use of transethosomes for enhancing the transdermal delivery of olmesartan medoxomil: in vitro, ex vivo, and in vivo evaluation
Introduction and aim Olmesartan medoxomil (OLM) is an antihypertensive drug with low oral
bioavailability due to extensive first-pass metabolism. This study aimed to prepare transetho …
bioavailability due to extensive first-pass metabolism. This study aimed to prepare transetho …
Methods for preparation of nanostructured lipid carriers
Construction of nanocarriers of different structures and properties have shown great promise
as delivery systems for a wide range of drugs to improve therapeutic effects and reduce side …
as delivery systems for a wide range of drugs to improve therapeutic effects and reduce side …
Recent progress in Zein nanoparticles: a promising approach for advancing Cancer therapy
A holistic approach is now necessary in cancer research to address the patients' discomfort
and alleviate the shortcomings in chemotherapy treatment. Despite the existence of several …
and alleviate the shortcomings in chemotherapy treatment. Despite the existence of several …
Development of a nanostructured lipid carrier (NLC) by a low-energy method, comparison of release kinetics and molecular dynamics simulation
Lipid nanocarriers have a great potential for improving the physicochemical characteristics
and behavior of poorly water-soluble drugs, such as aqueous dispersibility and oral …
and behavior of poorly water-soluble drugs, such as aqueous dispersibility and oral …
[HTML][HTML] Lipid-based nanoparticles: Enhanced cellular uptake via surface thiolation
The aim of this study was to evaluate the uptake mechanism of thiolated nanostructured lipid
carriers (NLCs). NLCs were decorated with a short-chain polyoxyethylene (10) stearyl ether …
carriers (NLCs). NLCs were decorated with a short-chain polyoxyethylene (10) stearyl ether …
[HTML][HTML] Nanomedicine-based disulfiram and metal ion co-delivery strategies for cancer treatment
Disulfiram (DSF) is a second-line drug for the clinical treatment of alcoholism and has long
been proven to be safe for use in clinical practice. In recent years, researchers have …
been proven to be safe for use in clinical practice. In recent years, researchers have …
Bile salt stabilized nanovesicles as a promising drug delivery technology: A general overview and future perspectives
Bile salts stabilized nanovesicles (bilosomes) have received tremendous attention in the
previous decade due to their vast preferabilities as well as the flexibility of their modification …
previous decade due to their vast preferabilities as well as the flexibility of their modification …