The hippocampal mossy fiber synapse, formed between axons of dentate gyrus granule
cells and dendrites of CA3 pyramidal neurons, is a key synapse in the trisynaptic circuitry of …

When animals interact with complex environments, their neural circuits must separate
overlap** patterns of activity that represent sensory and motor information. Pattern …

Throughout life, new neurons are continuously added to the dentate gyrus. As this
continuous addition remodels hippocampal circuits, computational models predict that …

The hippocampal dentate gyrus is often viewed as a segregator of upstream information.
Physiological support for such function has been hampered by a lack of well-defined …

Mossy cells comprise a large fraction of the cells in the hippocampal dentate gyrus,
suggesting that their function in this region is important. They are vulnerable to ischaemia …

LTP and LTD, the long-term potentiation and depression of excitatory synaptic transmission,
are widespread phenomena expressed at possibly every excitatory synapse in the …

Theta oscillations represent the" on-line" state of the hippocampus. The extracellular
currents underlying theta waves are generated mainly by the entorhinal input, CA3 …

The mammalian forebrain is constructed from ensembles of neurons that form local
microcircuits giving rise to the exquisite cognitive tasks the mammalian brain can perform …

Neurological illnesses, including cognitive impairment, memory decline and dementia, affect
over 50 million people worldwide, imposing a substantial burden on individuals and society …

Adult neurogenesis is the creation of new neurons which integrate into the existing neural
circuit of the adult brain. Recent evidence suggests that adult hippocampal neurogenesis …