Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …
dependent dementia. There is currently no effective treatment for AD, which may be …
The amyloid-β oligomer hypothesis: beginning of the third decade
The amyloid-β oligomer (AβO) hypothesis was introduced in 1998. It proposed that the brain
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …
New insights into the genetic etiology of Alzheimer's disease and related dementias
Abstract Characterization of the genetic landscape of Alzheimer's disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
Antibody-mediated targeting of human microglial leukocyte Ig-like receptor B4 attenuates amyloid pathology in a mouse model
Microglia help limit the progression of Alzheimer's disease (AD) by constraining amyloid-β
(Aβ) pathology, effected through a balance of activating and inhibitory intracellular signals …
(Aβ) pathology, effected through a balance of activating and inhibitory intracellular signals …
TREM2 is a receptor for β-amyloid that mediates microglial function
Mutations in triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to
increased Alzheimer's disease (AD) risk. Neurobiological functions of TREM2 and its …
increased Alzheimer's disease (AD) risk. Neurobiological functions of TREM2 and its …
Complement and microglia mediate early synapse loss in Alzheimer mouse models
Synapse loss in Alzheimer's disease (AD) correlates with cognitive decline. Involvement of
microglia and complement in AD has been attributed to neuroinflammation, prominent late in …
microglia and complement in AD has been attributed to neuroinflammation, prominent late in …
CD47 protects synapses from excess microglia-mediated pruning during development
EK Lehrman, DK Wilton, EY Litvina, CA Welsh… - Neuron, 2018 - cell.com
Microglia regulate synaptic circuit remodeling and phagocytose synaptic material in the
healthy brain; however, the mechanisms directing microglia to engulf specific synapses and …
healthy brain; however, the mechanisms directing microglia to engulf specific synapses and …
Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy
AA Barkal, K Weiskopf, KS Kao, SR Gordon… - Nature …, 2018 - nature.com
Exciting progress in the field of cancer immunotherapy has renewed the urgency of the need
for basic studies of immunoregulation in both adaptive cell lineages and innate cell …
for basic studies of immunoregulation in both adaptive cell lineages and innate cell …
Functions of immune checkpoint molecules beyond immune evasion
Y Zhang, J Zheng - Regulation of cancer immune checkpoints: molecular …, 2020 - Springer
Immune checkpoint molecules, including inhibitory and stimulatory immune checkpoint
molecules, are defined as ligand–receptor pairs that exert inhibitory or stimulatory effects on …
molecules, are defined as ligand–receptor pairs that exert inhibitory or stimulatory effects on …
Alzheimer disease pathogenesis: insights from molecular and cellular biology studies of oligomeric Aβ and tau species
XQ Chen, WC Mobley - Frontiers in Neuroscience, 2019 - frontiersin.org
Alzheimer disease (AD) represents an oncoming epidemic that without an effective
treatment promises to exact extraordinary human and financial burdens. Studies of …
treatment promises to exact extraordinary human and financial burdens. Studies of …