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Protein design: From the aspect of water solubility and stability
Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …
sequence and 3D-conformation. Their manipulation represents important aspects of the …
Engineering self-assembling protein nanoparticles for therapeutic delivery
Despite remarkable advances over the past several decades, many therapeutic
nanomaterials fail to overcome major in vivo delivery barriers. Controlling immunogenicity …
nanomaterials fail to overcome major in vivo delivery barriers. Controlling immunogenicity …
Hallucinating symmetric protein assemblies
Deep learning generative approaches provide an opportunity to broadly explore protein
structure space beyond the sequences and structures of natural proteins. Here, we use deep …
structure space beyond the sequences and structures of natural proteins. Here, we use deep …
Designed proteins assemble antibodies into modular nanocages
INTRODUCTION Antibodies that bind tightly to targets of interest play central roles in
biological research and medicine. Clusters of antibodies, typically generated by fusing …
biological research and medicine. Clusters of antibodies, typically generated by fusing …
Cryo-EM structure determination of small therapeutic protein targets at 3 Å-resolution using a rigid imaging scaffold
Cryoelectron microscopy (Cryo-EM) has enabled structural determination of proteins larger
than about 50 kDa, including many intractable by any other method, but it has largely failed …
than about 50 kDa, including many intractable by any other method, but it has largely failed …
Reconfigurable asymmetric protein assemblies through implicit negative design
Asymmetric multiprotein complexes that undergo subunit exchange play central roles in
biology but present a challenge for design because the components must not only contain …
biology but present a challenge for design because the components must not only contain …
Rapid and automated design of two-component protein nanomaterials using ProteinMPNN
The design of protein–protein interfaces using physics-based design methods such as
Rosetta requires substantial computational resources and manual refinement by expert …
Rosetta requires substantial computational resources and manual refinement by expert …
De novo design of obligate ABC-type heterotrimeric proteins
The de novo design of three protein chains that associate to form a heterotrimer (but not any
of the possible two-chain heterodimers) and that can drive the assembly of higher-order …
of the possible two-chain heterodimers) and that can drive the assembly of higher-order …
[HTML][HTML] Putting on molecular weight: Enabling cryo-EM structure determination of sub-100-kDa proteins
Significant advances in the past decade have enabled high-resolution structure
determination of a vast variety of proteins by cryogenic electron microscopy single particle …
determination of a vast variety of proteins by cryogenic electron microscopy single particle …
Antigen spacing on protein nanoparticles influences antibody responses to vaccination
Immunogen design approaches aim to control the specificity and quality of antibody
responses elicited by next-generation vaccines. Here, we use computational protein design …
responses elicited by next-generation vaccines. Here, we use computational protein design …