Homologous recombination (HR) serves to eliminate deleterious lesions, such as double-
stranded breaks and interstrand crosslinks, from chromosomes. HR is also critical for the …

The process of homologous recombination is a major DNA repair pathway that operates on
DNA double-strand breaks, and possibly other kinds of DNA lesions, to promote error-free …

BRCA2-mutant cells are defective in homologous recombination, making them vulnerable to
the inactivation of other pathways for the repair of DNA double-strand breaks (DSBs). This …

Cryoelectron microscopy of biological molecules is among the hottest growth areas in
biophysics and structural biology at present, and Frank is arguably the most distinguished …

The efficient repair of double-strand breaks in DNA is critical for the maintenance of genome
stability and cell survival. Homologous recombination provides an efficient and faithful …

▪ Abstract The process of homologous recombination promotes error-free repair of double-
strand breaks and is essential for meiosis. Central to the process of homologous …

The human genome, comprising three billion base pairs coding for 30000–40000 genes, is
constantly attacked by endogenous reactive metabolites, therapeutic drugs and a plethora of …

Maintenance of genomic integrity and stable transmission of genetic information depend on
a number of DNA repair processes. Failure to faithfully perform these processes can result in …

Numerous agents of endogenous and exogenous origin damage DNA in our genome.
There are several DNA‐repair pathways that recognize lesions in DNA and remove them …

Through pairing and shuffling of related DNA sequences, homologous recombination (HR) 1
serves to create genetic diversity. In both mitotic and meiotic cells, HR is also an important …