[HTML][HTML] Antibiotics in the clinical pipeline as of December 2022

MS Butler, IR Henderson, RJ Capon… - The Journal of …, 2023 - nature.com
The need for new antibacterial drugs to treat the increasing global prevalence of drug-
resistant bacterial infections has clearly attracted global attention, with a range of existing …

Gallium liquid metal: nanotoolbox for antimicrobial applications

VK Truong, A Hayles, R Bright, TQ Luu, MD Dickey… - ACS …, 2023 - ACS Publications
The proliferation of drug resistance in microbial pathogens poses a significant threat to
human health. Hence, treatment measures are essential to surmount this growing problem …

Biomedical metal–organic framework materials: perspectives and challenges

A Wang, M Walden, R Ettlinger… - Advanced functional …, 2024 - Wiley Online Library
Metal–organic framework (MOF) materials are gaining significant interest in biomedical
research, owing to their high porosity, crystallinity, and structural and compositional diversity …

Silver─ Gallium nano‐amalgamated particles as a novel, biocompatible solution for antibacterial coatings

TT Nguyen, P Zhang, J Bi, NH Nguyen… - Advanced Functional …, 2024 - Wiley Online Library
Bacterial infections account for countless deaths globally. Antibiotics are the primary
countermeasure; however, the alarming spread of antibiotic‐resistant strains necessitates …

Biodegradable oxygen-evolving metalloantibiotics for spatiotemporal sono-metalloimmunotherapy against orthopaedic biofilm infections

Z Su, D Xu, X Hu, W Zhu, L Kong, Z Qian, J Mei… - Nature …, 2024 - nature.com
Pathogen-host competition for manganese and intricate immunostimulatory pathways
severely attenuates the efficacy of antibacterial immunotherapy against biofilm infections …

Size and charge effects of metal nanoclusters on antibacterial mechanisms

HT Draviana, I Fitriannisa, M Khafid… - Journal of …, 2023 - Springer
Nanomaterials, specifically metal nanoclusters (NCs), are gaining attention as a promising
class of antibacterial agents. Metal NCs exhibit antibacterial properties due to their …

Harnessing transition metal scaffolds for targeted antibacterial therapy

C Weng, YLK Tan, WG Koh… - Angewandte Chemie …, 2023 - Wiley Online Library
Antimicrobial resistance, caused by persistent adaptation and growing resistance of
pathogenic bacteria to overprescribed antibiotics, poses one of the most serious and urgent …

Ion-doped calcium phosphate-based coatings with antibacterial properties

M Fosca, A Streza, IV Antoniac, G Vadalà… - Journal of functional …, 2023 - mdpi.com
Ion-substituted calcium phosphate (CP) coatings have been extensively studied as
promising materials for biomedical implants due to their ability to enhance biocompatibility …

Structure elucidation {single X-ray crystal diffraction studies, Hirshfeld surface analysis, DFT} and antibacterial studies of sulfonamide functionalized Schiff base …

WA Siddiqui, MA Raza, A Ashraf, M Ashfaq… - Journal of Molecular …, 2024 - Elsevier
Microbial infections tremendously affect the human health and can be cured by antimicrobial
agents. In this regard, the copper and zinc complexes of a sulfonamide functionalized Schiff …

Bismuth-based drugs sensitize Pseudomonas aeruginosa to multiple antibiotics by disrupting iron homeostasis

Y **a, X Wei, P Gao, C Wang, A De Jong… - Nature …, 2024 - nature.com
Pseudomonas aeruginosa infections are difficult to treat due to rapid development of
antibiotic drug resistance. The synergistic combination of already-in-use drugs is an …