Metabolic inflammation and insulin resistance in obesity

H Wu, CM Ballantyne - Circulation research, 2020 - Am Heart Assoc
Obesity is becoming an epidemic in the United States and worldwide and increases risk for
many diseases, particularly insulin resistance, type 2 diabetes mellitus, and cardiovascular …

Multiple parallel hits hypothesis in nonalcoholic fatty liver disease: revisited after a decade

H Tilg, TE Adolph, AR Moschen - Hepatology, 2021 - journals.lww.com
Nonalcoholic fatty liver disease (NAFLD) is an epidemic liver disease, affecting
approximately one quarter of the entire population in the world.(1) This disease …

Clinical characteristics and outcomes of patients with severe covid-19 with diabetes

Y Yan, Y Yang, F Wang, H Ren, S Zhang… - BMJ open diabetes …, 2020 - drc.bmj.com
Objective This study explores the clinical characteristics of patients with diabetes with severe
covid-19, and the association of diabetes with survival duration in patients with severe covid …

Crosstalk of inflammatory cytokines within the breast tumor microenvironment

O Habanjar, R Bingula, C Decombat… - International journal of …, 2023 - mdpi.com
Several immune and immunocompetent cells, including dendritic cells, macrophages,
adipocytes, natural killer cells, T cells, and B cells, are significantly correlated with the …

Adipokines: new potential therapeutic target for obesity and metabolic, rheumatic, and cardiovascular diseases

L Recinella, G Orlando, C Ferrante… - Frontiers in …, 2020 - frontiersin.org
Besides its role as an energy storage organ, adipose tissue can be viewed as a dynamic
and complex endocrine organ, which produces and secretes several adipokines, including …

Adapting to obesity with adipose tissue inflammation

SM Reilly, AR Saltiel - Nature Reviews Endocrinology, 2017 - nature.com
Adipose tissue not only has an important role in the storage of excess nutrients but also
senses nutrient status and regulates energy mobilization. An overall positive energy balance …

[HTML][HTML] White adipose tissue dysfunction in obesity and aging

M Reyes-Farias, J Fos-Domenech, D Serra… - Biochemical …, 2021 - Elsevier
Both obesity and aging are associated with the development of metabolic diseases such as
type 2 diabetes and cardiovascular disease. Chronic low-grade inflammation of adipose …

Skeletal muscle inflammation and insulin resistance in obesity

H Wu, CM Ballantyne - The Journal of clinical investigation, 2017 - Am Soc Clin Investig
Obesity is associated with chronic inflammation, which contributes to insulin resistance and
type 2 diabetes mellitus. Under normal conditions, skeletal muscle is responsible for the …

Obesity-associated microbiomes instigate visceral adipose tissue inflammation by recruitment of distinct neutrophils

D Shantaram, R Hoyd, AM Blaszczak, L Antwi… - Nature …, 2024 - nature.com
Neutrophils are increasingly implicated in chronic inflammation and metabolic disorders.
Here, we show that visceral adipose tissue (VAT) from individuals with obesity contains …

Obesity and inflammation

J Karczewski, E Śledzińska, A Baturo, I Jończyk… - European cytokine …, 2018 - Springer
The prevalence of obesity has recently increased dramatically and has contributed to the
increasing prevalence of various pathological conditions, including type 2 diabetes mellitus …