ER stress and the unfolded protein response
Conformational diseases are caused by mutations altering the folding pathway or final
conformation of a protein. Many conformational diseases are caused by mutations in …
conformation of a protein. Many conformational diseases are caused by mutations in …
Transport between the cell nucleus and the cytoplasm
▪ Abstract The compartmentation of eukaryotic cells requires all nuclear proteins to be
imported from the cytoplasm, whereas, for example, transfer RNAs, messenger RNAs, and …
imported from the cytoplasm, whereas, for example, transfer RNAs, messenger RNAs, and …
Molecular basis of human nuclear and mitochondrial tRNA 3′ processing
Eukaryotic transfer RNA (tRNA) precursors undergo sequential processing steps to become
mature tRNAs. In humans, ELAC2 carries out 3′ end processing of both nucleus-encoded …
mature tRNAs. In humans, ELAC2 carries out 3′ end processing of both nucleus-encoded …
[HTML][HTML] MicroRNA maturation: stepwise processing and subcellular localization
MicroRNAs (miRNAs) constitute a novel, phylogenetically extensive family of small RNAs (∼
22 nucleotides) with potential roles in gene regulation. Apart from the finding that miRNAs …
22 nucleotides) with potential roles in gene regulation. Apart from the finding that miRNAs …
An expanded eukaryotic genetic code
We describe a general and rapid route for the addition of unnatural amino acids to the
genetic code of Saccharomyces cerevisiae. Five amino acids have been incorporated into …
genetic code of Saccharomyces cerevisiae. Five amino acids have been incorporated into …
Expanding the genetic code
Although chemists can synthesize virtually any small organic molecule, our ability to
rationally manipulate the structures of proteins is quite limited, despite their involvement in …
rationally manipulate the structures of proteins is quite limited, despite their involvement in …
Extensive terminal and asymmetric processing of small RNAs from rRNAs, snoRNAs, snRNAs, and tRNAs
Deep sequencing studies frequently identify small RNA fragments of abundant RNAs. These
fragments are thought to represent degradation products of their precursors. Using …
fragments are thought to represent degradation products of their precursors. Using …
Regulatory roles of tRNA-derived RNA fragments in human pathophysiology
Hundreds of tRNA genes and pseudogenes are encoded by the human genome. tRNAs are
the second most abundant type of RNA in the cell. Advancement in deep-sequencing …
the second most abundant type of RNA in the cell. Advancement in deep-sequencing …
Metazoan tRNA introns generate stable circular RNAs in vivo
We report the discovery of a class of abundant circular noncoding RNAs that are produced
during metazoan tRNA splicing. These transcripts, termed tRNA intronic circular (tric) RNAs …
during metazoan tRNA splicing. These transcripts, termed tRNA intronic circular (tric) RNAs …
RNA quality control in eukaryotes
Eukaryotic cells contain numerous RNA quality-control systems that are important for
sha** the transcriptome of eukaryotic cells. These systems not only prevent accumulation …
sha** the transcriptome of eukaryotic cells. These systems not only prevent accumulation …