Increased cardiovascular disease in aging is partly a consequence of the vascular
endothelial cell (EC) senescence and associated vascular dysfunction. In this contest, EC …

The regulatory mechanisms by which hydrogen peroxide (H 2 O 2) modulates the activity of
transcription factors in bacteria (OxyR and PerR), lower eukaryotes (Yap1, Maf1, Hsf1 and …

Melatonin is an essential phytohormone in the regulation of many plant processes, including
during plant development and in response to stress. Pathogen infections cause serious …

Cerebrovascular endothelial cells (CECs) are integral components of both the blood‐brain
barrier (BBB) and the neurovascular unit (NVU). As the primary cell type of the BBB, CECs …

Aims In this study, we explored the underlying mechanisms of protective effects of rhein
against intestinal barrier injury in a rat model, induced by intraperitoneal injection of …

Rheum rhabarbarum has been widely used as a herbal medicine and food in China. The
objective of this study was to investigate the cytoprotective action and underlying …

Purposes We have previously reported that Ginsenoside Rb1 may effectively prevent
HUVECs from senescence, however, the detailed mechanism has not demonstrated up to …

Background and aims Intestinal epithelial barrier and intestinal inflammation play
indispensable roles in the development of intestinal diseases. The major aims of the current …

Endothelial cell senescence is closely related to the occurrence of cardiovascular diseases
and microRNAs (miRNAs/miRs) are considered as therapeutic targets for cardiovascular …

Ethnopharmacological relevance Paeonol is a phenolic compound isolated mainly from
Moutan cortex, root bark of Chinese Peony tree. Moutan cortex holds a significant value in …