Carbonic anhydrase inhibitors
At least 14 different carbonic anhydrase (CA, EC 4.2. 1.1) isoforms were isolated in higher
vertebrates, where these zinc enzymes play crucial physiological roles. Some of these …
vertebrates, where these zinc enzymes play crucial physiological roles. Some of these …
The many faces of the adamantyl group in drug design
J Liu, D Obando, V Liao, T Lifa, R Codd - European journal of medicinal …, 2011 - Elsevier
Adamantyl-based compounds are used clinically for the treatment of neurological
conditions, as anti-viral agents and as agents against type 2 diabetes. The value of the …
conditions, as anti-viral agents and as agents against type 2 diabetes. The value of the …
Carbonic anhydrase inhibitors
CAs (EC 4.2. 1.1) are wide-spread zinc enzymes, present in mammals in at least 14 different
isoforms. Some of these isozymes are cytosolic (CA I, CA II, CA III, CA VII), others are …
isoforms. Some of these isozymes are cytosolic (CA I, CA II, CA III, CA VII), others are …
Metal complexes as enzyme inhibitors
Metal complexes are gaining wider applications as enzyme inhibitors for disease treatments.
Factors such as specificity, bioavailability, compensatory effects and complex stability are …
Factors such as specificity, bioavailability, compensatory effects and complex stability are …
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or …
A Scozzafava, L Menabuoni, F Mincione… - Journal of medicinal …, 1999 - ACS Publications
Reaction of several aromatic/heterocyclic sulfonamides containing a free amino, imino,
hydrazino, or hydroxyl group, with 2, 3-pyridinedicarboxylic anhydride or 2, 6 …
hydrazino, or hydroxyl group, with 2, 3-pyridinedicarboxylic anhydride or 2, 6 …
New anticonvulsant agents
B Malawska - Frontiers in Medicinal Chemistry: Volume 4, 2009 - benthamdirect.com
The search for antiepileptic compounds with more selective activity and lower toxicity
continues to be an area of intensive investigation in medicinal chemistry. This review …
continues to be an area of intensive investigation in medicinal chemistry. This review …
In vitro inhibition of α-carbonic anhydrase isozymes by some phenolic compounds
Carbonic anhydrase inhibitors (CAIs) are a class of pharmaceuticals used as antiglaucoma
agents, diuretics, antiepileptics, in the management of mountain sickness, gastric and …
agents, diuretics, antiepileptics, in the management of mountain sickness, gastric and …
Carbonic anhydrase inhibitors-Part 94. 1, 3, 4-Thiadiazole-2-sulfonamide derivatives as antitumor agents?
Potent sulfonamide inhibitors of the zinc enzyme carbonic anhydrase (CA, EC 4.2. 1.1),
derivatives of 1, 3, 4-thiadiazole-2-sulfonamide, possessing inhibition constants in the range …
derivatives of 1, 3, 4-thiadiazole-2-sulfonamide, possessing inhibition constants in the range …
Carbonic anhydrase inhibitors: anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties
B Masereel, S Rolin, F Abbate… - Journal of Medicinal …, 2002 - ACS Publications
A series of aromatic/heterocyclic sulfonamides incorporating valproyl moieties were
prepared to design antiepileptic compounds possessing in their structure two moieties …
prepared to design antiepileptic compounds possessing in their structure two moieties …
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino− polycarboxylate tails and of their metal …
A Scozzafava, L Menabuoni, F Mincione… - Journal of medicinal …, 2002 - ACS Publications
Reaction of polyamino-polycarboxylic acids or their dianhydrides with aromatic/heterocyclic
sulfonamides possessing a free amino/imino/hydrazino/hydroxy group afforded mono-and …
sulfonamides possessing a free amino/imino/hydrazino/hydroxy group afforded mono-and …