Embryogenesis, tissue repair and cancer metastasis rely on collective cell migration. In vitro
studies propose that cells are stiffer while migrating in stiff substrates, but softer when plated …

The extracellular matrix (ECM) is a highly complex structure through which biochemical and
mechanical signals are transmitted. In processes of cell migration, the ECM also acts as a …

Stem cell‐derived kidney organoids contain nephron segments that recapitulate
morphological and functional aspects of the human kidney. However, directed differentiation …

Cell spheroids (CSs) are three-dimensional models in vitro that have a microenvironment
similar to tissues. Such three-dimensional cellular structures are of great interest in the field …

It is well established that the early malignant tumor invades surrounding extracellular matrix
(ECM) in a manner that depends upon material properties of constituent cells, surrounding …

Morphogenesis is governed by the interplay of molecular signals and mechanical forces
across multiple length scales. The last decade has seen tremendous advances in our …

In recent years, three-dimensional (3D) spheroid technology has emerged as a crucial
instrument in the realm of cancer research, offering a near-physiological model for probing …

We determine how intercellular interactions and mechanical pressure experienced by single
cells regulate cell proliferation using a minimal computational model for three-dimensional …

Abstract Models of confluent tissues are built out of tessellations of the space (both in two
and three dimensions) in which the cost function is constructed in such a way that individual …

The growth of a tissue, which depends on cell–cell interactions and biologically relevant
processes such as cell division and apoptosis, is regulated by a mechanical feedback …