In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …

The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …

Increasing numbers of studies implicate abnormal DNA methylation in cancer and many non-
malignant diseases. This is consistent with numerous findings about differentiation …

Bisulfite sequencing has been the gold standard for map** DNA modifications including 5-
methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) for decades,,–. However, this …

As one of the most abundant and well-studied epigenetic modifications, DNA methylation
plays an essential role in normal development and cellular biology. Global alterations to the …

DNA methylation is a major epigenetic mark with important roles in genetic regulation.
Methylated cytosines are found primarily at CpG dinucleotides, but are also found at non …

Werner syndrome (WS) is a premature aging disorder caused by WRN protein deficiency.
Here, we report on the generation of a human WS model in human embryonic stem cells …

C-to-T transitions in CpG dinucleotides are the most prevalent mutations in human cancers
and genetic diseases. These mutations have been attributed to deamination of 5 …

Mutations in methyl CpG binding protein 2 (MeCP2) are the major cause of Rett syndrome
(RTT), a rare neurodevelopmental disorder with a notable period of developmental …

DNA methylation at CpG dinucleotides is an important epigenetic regulator common to
virtually all mammalian cell types, but recent evidence indicates that during early postnatal …