Tuberculosis (TB) is an infectious disease that poses a serious threat to human health.
Rifampin (RIF) is an important first-line anti-TB drug, and rifampin resistance (RIF-R) is a key …

Objectives: With the spread of multidrug-resistant tuberculosis (MDR-TB) there is increasing
demand for new accurate and cost-effective tools for rapid drug susceptibility testing (DST) …

The chromosome of Mycobacterium tuberculosis encodes five type VII secretion systems
(ESX‐1–ESX‐5). While the role of the ESX‐1 and ESX‐3 systems in M. tuberculosis has …

Objectives To evaluate the role of piperine as an inhibitor of Rv1258c of Mycobacterium
tuberculosis. Methods Rifampicin, in combination with piperine, was tested against M …

Objectives The reference standard methods for drug susceptibility testing (DST) of M.
tuberculosis are very slow to give results, and due to the emergence of multidrug-resistant …

In this study, we describe the antimycobacterial activity of two pigments, violacein, a purple
violet pigment from Janthinobacterium sp. Ant5-2 (J-PVP), and flexirubin, a yellow-orange …

A limited number of anti-tuberculosis drug candidates with novel mode of action have
entered clinical trials in recent years. ATP synthase is one such validated drug target which …

Background This study aimed to analyze the association of mutation patterns in gyrA and
gyrB genes and the ofloxacin resistance levels in clinical Mycobacterium tuberculosis …

Mycobacterium tuberculosis is a global public health concern, particularly with the
emergence of drug-resistant strains. Immediate identification of drug-resistant strains is …

Shikimate kinase of Mycobacterium tuberculosis is involved in the biosynthesis of aromatic
amino acids through shikimate pathway. The enzyme is essential for the survival of M …