Precision medicine is a new frontier in healthcare that uses scientific methods to customize
medical treatment to the individual genes, anatomy, physiology, and lifestyle of each person …

Autoimmune rheumatic diseases (ARDs) involve multiple organs including the heart and
vasculature. Despite novel treatments, patients with ARDs still experience a reduced life …

Abstract Background and Objective: Cardiac electrophysiology is a medical specialty with a
long and rich tradition of computational modeling. Nevertheless, no community standard for …

Mathematical models of the human heart are evolving to become a cornerstone of precision
medicine and support clinical decision making by providing a powerful tool to understand …

Hypertrophic cardiomyopathy (HCM), the most common inherited heart disease, is still
orphan of a specific drug treatment. The erroneous consideration of HCM as a rare disease …

Cardiomyopathies have unresolved genotype–phenotype relationships and lack disease-
specific treatments. Here we provide a framework to identify genotype-specific …

Mechano‐electric regulations (MER) play an important role in the maintenance of cardiac
performance. Mechano‐calcium and mechano‐electric feedback (MCF and MEF) pathways …

Rationale: Calcium transient analysis is central to understanding inherited and acquired
cardiac physiology and disease. Although the development of novel calcium reporters …

We developed a novel patient-specific computational model for the numerical simulation of
ventricular electromechanics in patients with ischemic cardiomyopathy (ICM). This model …

Atrial fibrillation (AF) is the most common sustained clinical arrhythmia, with a lifetime
incidence of up to 37%, and is a major contributor to population morbidity and mortality …