Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses

Y Chen, X Zhao, H Zhou, H Zhu, S Jiang… - Nature Reviews …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently emerged
pathogenic human coronavirus that belongs to the sarbecovirus lineage of the genus …

The impact of pre-existing cross-reactive immunity on SARS-CoV-2 infection and vaccine responses

SM Murray, AM Ansari, J Frater, P Klenerman… - Nature Reviews …, 2023 - nature.com
Pre-existing cross-reactive immune responses to severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) proteins in infection-naive subjects have been described by …

Circular RNA vaccine in disease prevention and treatment

D Niu, Y Wu, J Lian - Signal transduction and targeted therapy, 2023 - nature.com
CircRNAs are a class of single-stranded RNAs with covalently linked head-to-tail topology.
In the decades since its initial discovery, their biogenesis, regulation, and function have …

B-cell and antibody responses to SARS-CoV-2: infection, vaccination, and hybrid immunity

D Lapuente, TH Winkler, M Tenbusch - Cellular & molecular …, 2024 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019
prompted scientific, medical, and biotech communities to investigate infection-and vaccine …

The role of vaccines in the COVID-19 pandemic: what have we learned?

F Krammer - Seminars in Immunopathology, 2024 - Springer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged late in 2019 and
caused the coronavirus disease 2019 (COVID-19) pandemic that has so far claimed …

Cryo-EM structure of SARS-CoV-2 postfusion spike in membrane

W Shi, Y Cai, H Zhu, H Peng, J Voyer, S Rits-Volloch… - Nature, 2023 - nature.com
The entry of SARS-CoV-2 into host cells depends on the refolding of the virus-encoded
spike protein from a prefusion conformation, which is metastable after cleavage, to a lower …

Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents

Y Cao, F Jian, Z Zhang, A Yisimayi, X Hao, L Bao… - Cell reports, 2022 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages have
escaped most receptor-binding domain (RBD)-targeting therapeutic neutralizing antibodies …

Prefusion-stabilized SARS-CoV-2 S2-only antigen provides protection against SARS-CoV-2 challenge

CL Hsieh, SR Leist, EH Miller, L Zhou… - Nature …, 2024 - nature.com
Abstract Ever-evolving SARS-CoV-2 variants of concern (VOCs) have diminished the
effectiveness of therapeutic antibodies and vaccines. Develo** a coronavirus vaccine that …

Viral membrane fusion: a dance between proteins and lipids

JM White, AE Ward, L Odongo… - Annual review of …, 2023 - annualreviews.org
There are at least 21 families of enveloped viruses that infect mammals, and many contain
members of high concern for global human health. All enveloped viruses have a dedicated …