Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes
The generation of islet-like endocrine clusters from human pluripotent stem cells (hPSCs)
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …
Predicting the Key Regulators of Cell Identity in Human Adult Pancreas
L Vanheer, F Fantuzzi, SK To, AA Schiavo… - bioRxiv, 2020 - biorxiv.org
Cellular identity during development is under the control of transcription factors that form
gene regulatory networks. However, the transcription factors and gene regulatory networks …
gene regulatory networks. However, the transcription factors and gene regulatory networks …
Mimicking Islet Development with Human Pluripotent Stem Cells
AL Faust, A Veres, DA Melton - Pluripotent Stem Cell Therapy for Diabetes, 2024 - Springer
The development of functional beta cells from human pluripotent stem cells (PSCs) offers a
promising approach for treating type 1 diabetes (T1D). However, current differentiation …
promising approach for treating type 1 diabetes (T1D). However, current differentiation …