Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-
modifying factors originally identified as part of an epigenetic cellular memory system that …

MicroRNAs (miRNAs) are critical regulators of gene expression. As miRNAs are frequently
deregulated in many human diseases, including cancer and immunological disorders, it is …

Polycomb group (PcG) proteins are epigenetic regulators of transcription that have key roles
in stem-cell identity, differentiation and disease. Mechanistically, they function within …

The sea lamprey (Petromyzon marinus) serves as a comparative model for reconstructing
vertebrate evolution. To enable more informed analyses, we developed a new assembly of …

H3K27me3 is deposited at promoters by the preferential association of Polycomb repressive
complex 2 (PRC2) with CpG-rich DNA elements regulating development by repressing gene …

Variability in induced pluripotent stem cell (iPSC) lines remains a concern for disease
modeling and regenerative medicine. We have used RNA-sequencing analysis and linear …

Promiscuous gene expression (PGE) by thymic epithelial cells (TEC) is essential for
generating a diverse T cell antigen receptor repertoire tolerant to self-antigens, and thus for …

Pluripotency of embryonic stem cells (ESCs) and induced pluripotent stem cells is regulated
by a well characterized gene transcription circuitry. The circuitry is assembled by ESC …

Impairment in gut epithelial integrity and barrier function is associated with many diseases.
The homeostasis of intestinal barrier is based on a delicate regulation of epithelial …

The precise, temporal order of gene expression during development is critical to ensure
proper lineage commitment, cell fate determination, and ultimately, organogenesis …