Molecular aspects of fructose metabolism and metabolic disease
Excessive sugar consumption is increasingly considered as a contributor to the emerging
epidemics of obesity and the associated cardiometabolic disease. Sugar is added to the diet …
epidemics of obesity and the associated cardiometabolic disease. Sugar is added to the diet …
[HTML][HTML] Nonalcoholic fatty liver disease (NAFLD) from pathogenesis to treatment concepts in humans
K Pafili, M Roden - Molecular Metabolism, 2021 - Elsevier
Background Nonalcoholic fatty liver disease (NAFLD) comprises hepatic alterations with
increased lipid accumulation (steatosis) without or with inflammation (nonalcoholic …
increased lipid accumulation (steatosis) without or with inflammation (nonalcoholic …
[HTML][HTML] Marked difference in liver fat measured by histology vs. magnetic resonance-proton density fat fraction: A meta-analysis
S Qadri, E Vartiainen, M Lahelma, K Porthan, A Tang… - JHEP reports, 2024 - Elsevier
Background & Aims Pathologists quantify liver steatosis as the fraction of lipid droplet-
containing hepatocytes out of all hepatocytes, whereas the magnetic resonance-determined …
containing hepatocytes out of all hepatocytes, whereas the magnetic resonance-determined …
Metabolic signature of hepatic fibrosis: from individual pathways to systems biology
ML Chang, SS Yang - Cells, 2019 - mdpi.com
Hepatic fibrosis is a major cause of morbidity and mortality worldwide, as it ultimately leads
to cirrhosis, which is estimated to affect up to 2% of the global population. Hepatic fibrosis is …
to cirrhosis, which is estimated to affect up to 2% of the global population. Hepatic fibrosis is …
Metabolomic and lipidomic biomarkers for premalignant liver disease diagnosis and therapy
In recent years, there has been a plethora of attempts to discover biomarkers that are more
reliable than α-fetoprotein for the early prediction and prognosis of hepatocellular carcinoma …
reliable than α-fetoprotein for the early prediction and prognosis of hepatocellular carcinoma …
The role of hepatic lipid composition in obesity‐related metabolic disease
Obesity is a primary antecedent to non‐alcoholic fatty liver disease whose cardinal feature is
excessive hepatic lipid accumulation. Although total hepatic lipid content closely associates …
excessive hepatic lipid accumulation. Although total hepatic lipid content closely associates …
Effect of oral exposure to titanium dioxide nanoparticles on lipid metabolism in Sprague-Dawley rats
Ingestion of titanium dioxide nanoparticles (TiO2 NPs) via dietary and environmental
exposure may pose health risks. The research about the potential effect of orally ingested …
exposure may pose health risks. The research about the potential effect of orally ingested …
MAFLD/NAFLD biopsy-free scoring systems for hepatic steatosis, NASH, and fibrosis diagnosis
NÁ Segura-Azuara, CD Varela-Chinchilla… - Frontiers in …, 2022 - frontiersin.org
Metabolic dysfunction-associated fatty liver disease (MAFLD), formerly known as
nonalcoholic fatty liver disease, is the most prevalent liver disorder worldwide. Historically …
nonalcoholic fatty liver disease, is the most prevalent liver disorder worldwide. Historically …
[HTML][HTML] Diabetes as a risk factor for MASH progression
S Gancheva, M Roden, L Castera - Diabetes Research and Clinical …, 2024 - Elsevier
Abstract Non-alcoholic (now: metabolic) steatohepatitis (MASH) is the progressive
inflammatory form of metabolic dysfunction-associated steatotic liver disease (MASLD) …
inflammatory form of metabolic dysfunction-associated steatotic liver disease (MASLD) …
The regulatory role and mechanism of autophagy in energy metabolism-related hepatic fibrosis
LS Hou, YW Zhang, H Li, W Wang, ML Huan… - Pharmacology & …, 2022 - Elsevier
Hepatic fibrosis is a key pathological process of chronic liver diseases, caused by alcohol,
toxic and aberrant energy metabolism. It progresses to cirrhosis or even hepatic carcinoma …
toxic and aberrant energy metabolism. It progresses to cirrhosis or even hepatic carcinoma …