Molecular aspects of fructose metabolism and metabolic disease

MA Herman, MJ Birnbaum - Cell metabolism, 2021 - cell.com
Excessive sugar consumption is increasingly considered as a contributor to the emerging
epidemics of obesity and the associated cardiometabolic disease. Sugar is added to the diet …

[HTML][HTML] Nonalcoholic fatty liver disease (NAFLD) from pathogenesis to treatment concepts in humans

K Pafili, M Roden - Molecular Metabolism, 2021 - Elsevier
Background Nonalcoholic fatty liver disease (NAFLD) comprises hepatic alterations with
increased lipid accumulation (steatosis) without or with inflammation (nonalcoholic …

[HTML][HTML] Marked difference in liver fat measured by histology vs. magnetic resonance-proton density fat fraction: A meta-analysis

S Qadri, E Vartiainen, M Lahelma, K Porthan, A Tang… - JHEP reports, 2024 - Elsevier
Background & Aims Pathologists quantify liver steatosis as the fraction of lipid droplet-
containing hepatocytes out of all hepatocytes, whereas the magnetic resonance-determined …

Metabolic signature of hepatic fibrosis: from individual pathways to systems biology

ML Chang, SS Yang - Cells, 2019 - mdpi.com
Hepatic fibrosis is a major cause of morbidity and mortality worldwide, as it ultimately leads
to cirrhosis, which is estimated to affect up to 2% of the global population. Hepatic fibrosis is …

Metabolomic and lipidomic biomarkers for premalignant liver disease diagnosis and therapy

D Beyoğlu, JR Idle - Metabolites, 2020 - mdpi.com
In recent years, there has been a plethora of attempts to discover biomarkers that are more
reliable than α-fetoprotein for the early prediction and prognosis of hepatocellular carcinoma …

The role of hepatic lipid composition in obesity‐related metabolic disease

SA Willis, SJ Bawden, S Malaikah… - Liver …, 2021 - Wiley Online Library
Obesity is a primary antecedent to non‐alcoholic fatty liver disease whose cardinal feature is
excessive hepatic lipid accumulation. Although total hepatic lipid content closely associates …

Effect of oral exposure to titanium dioxide nanoparticles on lipid metabolism in Sprague-Dawley rats

Z Chen, S Han, P Zheng, D Zhou, S Zhou, G Jia - Nanoscale, 2020 - pubs.rsc.org
Ingestion of titanium dioxide nanoparticles (TiO2 NPs) via dietary and environmental
exposure may pose health risks. The research about the potential effect of orally ingested …

MAFLD/NAFLD biopsy-free scoring systems for hepatic steatosis, NASH, and fibrosis diagnosis

NÁ Segura-Azuara, CD Varela-Chinchilla… - Frontiers in …, 2022 - frontiersin.org
Metabolic dysfunction-associated fatty liver disease (MAFLD), formerly known as
nonalcoholic fatty liver disease, is the most prevalent liver disorder worldwide. Historically …

[HTML][HTML] Diabetes as a risk factor for MASH progression

S Gancheva, M Roden, L Castera - Diabetes Research and Clinical …, 2024 - Elsevier
Abstract Non-alcoholic (now: metabolic) steatohepatitis (MASH) is the progressive
inflammatory form of metabolic dysfunction-associated steatotic liver disease (MASLD) …

The regulatory role and mechanism of autophagy in energy metabolism-related hepatic fibrosis

LS Hou, YW Zhang, H Li, W Wang, ML Huan… - Pharmacology & …, 2022 - Elsevier
Hepatic fibrosis is a key pathological process of chronic liver diseases, caused by alcohol,
toxic and aberrant energy metabolism. It progresses to cirrhosis or even hepatic carcinoma …