The development of potent, specific, and pharmacologically viable chemical probes and
therapeutics is a central focus of chemical biology and therapeutic development. However, a …

The BIOPEP-UWM™ database of bioactive peptides (formerly BIOPEP) has recently
become a popular tool in the research on bioactive peptides, especially on these derived …

Since the definition of bioactive peptides has been firstly published, the knowledge about
these molecules is still being improved. It stems from the progress in research methods …

Abstract Structure determination of linear peptides of 5–50 amino acids in aqueous solution
and interacting with proteins is a key aspect in structural biology. PEP-FOLD3 is a novel …

Abstract BitterDB (http://bitterdb. agri. huji. ac. il) was introduced in 2012 as a central
resource for information on bitter-tasting molecules and their receptors. The information in …

Acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and beta-secretase 1 (BACE 1)
play vital roles in the development and progression of Alzheimer's disease (AD). The …

The transmembrane serine protease 2 (TMPRSS2) primes the SARS-CoV-2 Spike (S)
protein for host cell entry and represents a promising target for COVID-19 therapy. Here we …

Language modeling applied to biological data has significantly advanced the prediction of
membrane penetration for small-molecule drugs and natural peptides. However, accurately …

All-hydrocarbon stapled peptides, with their covalent side-chain constraints, provide
enhanced proteolytic stability and membrane permeability, making them superior to linear …

The affinity of peptides is a crucial factor in studying peptide–protein interactions. Despite
the development of various techniques to evaluate peptide–receptor affinity, the results may …