Runx2 (runt related transcription factor 2) and Sp7 (Sp7 transcription factor 7) are crucial
transcription factors for bone development. The cotranscription factor Cbfb (core binding …

Osteogenesis Imperfecta (OI) comprises a heterogeneous group of patients who share bone
fragility and deformities as the main characteristics, albeit with different degrees of severity …

Osteogenesis imperfecta (OI) is a heterogeneous heritable skeletal dysplasia characterized
by bone fragility and deformity, growth deficiency, and other secondary connective tissue …

SP7/Osterix is a transcription factor critical for osteoblast maturation and bone formation.
Homozygous loss-of-function mutations in SP7 cause osteogenesis imperfecta type XII, but …

Abstract Purpose of Review The purpose of this review is to summarize the different roles of
the transcription factor SP7 in regulating bone formation and remodeling, discuss current …

Osteoporosis is a skeletal disorder with enhanced bone fragility, usually affecting the elderly.
It is very rare in children and young adults and the definition is not only based on a low BMD …

Back pain is a common condition with a high social impact and represents a global health
burden. Intervertebral disc disease (IVDD) is one of the major causes of back pain; no …

Osteoblast differentiation is a tightly regulated process in which key transcription factors
(TFs) and their target genes constitute gene regulatory networks (GRNs) under the control of …

ABSTRACT Early‐onset osteoporosis (EOOP), characterized by low bone mineral density
(BMD) and fractures, affects children, premenopausal women and men aged< 50 years …

Mutations in SP7 (encoding osterix) have been identified as a rare cause of recessive
osteogenesis imperfecta ('OI type XII') and in one case of dominant juvenile Paget's disease …