X-ray diffraction (XRD) is a powerful nondestructive technique for characterizing crystalline
materials. It provides information on structures, phases, preferred crystal orientations …

Highlights•Discovery of pharmaceutical cocrystals has evolved from serendipity to
design.•Contains an overview of all commercially available pharmaceutical …

Active pharmaceutical ingredients (APIs) may exist in various solid forms, which can lead to
differences in the intermolecular interactions, affecting the internal energy and enthalpy, and …

The entire pharmaceutical sector is in an urgent need of both innovative technological
solutions and fundamental scientific work, enabling the production of highly engineered …

Most people are familiar with the fact that diamond and graphite are both composed only of
carbon; yet they have very different properties which result from the very different structures …

Almost 100 years after the discovery of the Raman scattering phenomenon, related
analytical techniques have emerged as important tools in biomedical sciences. Raman …

Within the Process Analytical Technology (PAT) framework, it is of utmost importance to
obtain critical process and formulation information during pharmaceutical processing …

Within the pharmaceutical industry, and elsewhere, the screening for new solid forms is a
mandatory exercise for both existing and new chemical entities. This contribution focuses on …

Mechanochemistry is considered an alternative attractive greener approach to prepare
diverse molecular compounds and has become an important synthetic tool in different fields …

Preformulation measurements are used to estimate the fraction absorbed in vivo for orally
administered compounds and thereby allow an early evaluation of the need for enabling …