Multigene families in Trypanosoma cruzi and their role in infectivity
The Trypanosoma cruzi genome contains the most widely expanded content (∼ 12,000
genes) of the trypanosomatids sequenced to date. This expansion is reflected in the high …
genes) of the trypanosomatids sequenced to date. This expansion is reflected in the high …
A sticky situation: When trypanosomatids attach to insect tissues
Transmission of trypanosomatids to their mammalian hosts requires a complex series of
developmental transitions in their insect vectors, including stable attachment to an insect …
developmental transitions in their insect vectors, including stable attachment to an insect …
CRISPR/Cas9-mediated endogenous C-terminal tagging of Trypanosoma cruzi genes reveals the acidocalcisome localization of the inositol 1, 4, 5-trisphosphate …
Methods for genetic manipulation of Trypanosoma cruzi, the etiologic agent of Chagas
disease, have been highly inefficient, and no endogenous tagging of genes has been …
disease, have been highly inefficient, and no endogenous tagging of genes has been …
IP3 receptor-mediated Ca2+ release from acidocalcisomes regulates mitochondrial bioenergetics and prevents autophagy in Trypanosoma cruzi
In contrast to animal cells, the inositol 1, 4, 5-trisphosphate receptor of Trypanosoma cruzi
(TcIP 3 R) localizes to acidocalcisomes instead of the endoplasmic reticulum. Here, we …
(TcIP 3 R) localizes to acidocalcisomes instead of the endoplasmic reticulum. Here, we …
Different Roles of Mitochondrial Calcium Uniporter Complex Subunits in Growth and Infectivity of Trypanosoma cruzi
Trypanosoma cruzi is the agent of Chagas disease, and the finding that this parasite
possesses a mitochondrial calcium uniporter (TcMCU) with characteristics similar to that of …
possesses a mitochondrial calcium uniporter (TcMCU) with characteristics similar to that of …
RNA-Seq reveals that overexpression of TcUBP1 switches the gene expression pattern toward that of the infective form of Trypanosoma cruzi
Trypanosomes regulate gene expression mainly by using posttranscriptional mechanisms.
Key factors responsible for carrying out this regulation are RNA-binding proteins, affecting …
Key factors responsible for carrying out this regulation are RNA-binding proteins, affecting …
Extensive flagellar remodeling during the complex life cycle of Paratrypanosoma, an early-branching trypanosomatid
Paratrypanosoma confusum is a monoxenous kinetoplastid flagellate that constitutes the
most basal branch of the highly diverse parasitic trypanosomatids, which include human …
most basal branch of the highly diverse parasitic trypanosomatids, which include human …
Transcriptomic analysis of N-terminal mutated Trypanosoma cruzi UBP1 knockdown underlines the importance of this RNA-binding protein in parasite development
KB Sabalette, VA Campo… - PLOS Neglected …, 2024 - journals.plos.org
Background During its life cycle, the human pathogen Trypanosoma cruzi must quickly
adapt to different environments, in which the variation in the gene expression of the …
adapt to different environments, in which the variation in the gene expression of the …
Genome evolution in trypanosomatid parasites
AP Jackson - Parasitology, 2015 - cambridge.org
A decade of genome sequencing has transformed our understanding of how trypanosomatid
parasites have evolved and provided fresh impetus to explaining the origins of parasitism in …
parasites have evolved and provided fresh impetus to explaining the origins of parasitism in …
Gene editing of putative cAMP and Ca2+‐regulated proteins using an efficient cloning‐free CRISPR/Cas9 system in Trypanosoma cruzi
Trypanosoma cruzi, the agent of Chagas disease, must adapt to a diversity of environmental
conditions that it faces during its life cycle. The adaptation to these changes is mediated by …
conditions that it faces during its life cycle. The adaptation to these changes is mediated by …