The role of platelets in immune-mediated inflammatory diseases

M Scherlinger, C Richez, GC Tsokos… - Nature Reviews …, 2023 - nature.com
Immune-mediated inflammatory diseases (IMIDs) are characterized by excessive and
uncontrolled inflammation and thrombosis, both of which are responsible for organ damage …

The immune nature of platelets revisited

A Maouia, J Rebetz, R Kapur, JW Semple - Transfusion medicine reviews, 2020 - Elsevier
Platelets are the primary cellular mediators of hemostasis and this function firmly acquaints
them with a variety of inflammatory processes. For example, platelets can act as circulating …

The era of thromboinflammation: platelets are dynamic sensors and effector cells during infectious diseases

L Guo, MT Rondina - Frontiers in immunology, 2019 - frontiersin.org
Platelets are anucleate cells produced by megakaryocytes. In recent years, a robust body of
literature supports the evolving role of platelets as key sentinel and effector cells in infectious …

Thrombosis as an intravascular effector of innate immunity

B Engelmann, S Massberg - Nature Reviews Immunology, 2013 - nature.com
Thrombosis is the most frequent cause of mortality worldwide and is closely linked to
haemostasis, which is the biological mechanism that stops bleeding after the injury of blood …

Emerging roles for platelets as immune and inflammatory cells

CN Morrell, AA Aggrey, LM Chapman… - Blood, The Journal of …, 2014 - ashpublications.org
Despite their small size and anucleate status, platelets have diverse roles in vascular
biology. Not only are platelets the cellular mediator of thrombosis, but platelets are also …

Platelets and the immune continuum

JW Semple, JE Italiano, J Freedman - Nature Reviews Immunology, 2011 - nature.com
Platelets are anucleate cells that are crucial mediators of haemostasis. Most immunologists
probably don't think about platelets every day, and may even consider these cells to …

Platelet signaling and disease: targeted therapy for thrombosis and other related diseases

J Yeung, W Li, M Holinstat - Pharmacological reviews, 2018 - Elsevier
Platelets are essential for clotting in the blood and maintenance of normal hemostasis.
Under pathologic conditions such as atherosclerosis, vascular injury often results in …

Platelets in immune response to virus and immunopathology of viral infections

ED Hottz, FA Bozza, PT Bozza - Frontiers in medicine, 2018 - frontiersin.org
Platelets are essential effector cells in hemostasis. Aside from their role in coagulation,
platelets are now recognized as major inflammatory cells with key roles in the innate and …

Shiga toxin-producing Escherichia coli: An overview

CL Gyles - Journal of animal science, 2007 - academic.oup.com
The objective of this review is to highlight the importance of cattle in human disease due to
Shiga toxin-producing Escherichia coli (STEC) and to discuss features of STEC that are …

Impaired intestinal barrier and tissue bacteria: pathomechanisms for metabolic diseases

L Massier, M Blüher, P Kovacs… - Frontiers in …, 2021 - frontiersin.org
An intact intestinal barrier, representing the interface between inner and outer environments,
is an integral regulator of health. Among several factors, bacteria and their products have …