Cells respond to protein-damaging (proteotoxic) stress by activation of the Heat Shock
Response (HSR). The HSR provides cells with an enhanced ability to endure proteotoxic …

Extracellular stimuli elicit a variety of responses, such as cell proliferation and differentiation,
through the cellular signalling system. Binding of growth factors to the respective receptor …

Ferroptosis is an iron-dependent form of non-apoptotic cell death, but its molecular
mechanism remains largely unknown. Here, we demonstrate that heat shock protein beta-1 …

Yellon, Derek M., and James M. Downey. Preconditioning the Myocardium: From Cellular
Physiology to Clinical Cardiology. Physiol Rev 83: 1113-1151, 2003; 10.1152/physrev …

Modern classification of the family of human small heat shock proteins (the so-called HSPB)
is presented, and the structure and properties of three members of this family are analyzed …

Heat shock proteins (Hsps) are a family of highly homologous chaperone proteins that are
induced in response to environmental, physical and chemical stresses and that limit the …

How a cell responds to stress is a central problem in cardiovascular biology. Diverse
physiological stresses (eg, heat, hemodynamics, mutant proteins, and oxidative injury) …

Vascular endothelial growth factor (VEGF) is a potent chemotactic agent for endothelial
cells. Yet the signalling pathways that modulate the motogenic effects of VEGF in vascular …

Abstract Heat shock protein 27 (HSP27) is a multidimensional protein which acts as a
protein chaperone and an antioxidant and plays a role in the inhibition of apoptosis and …

By gating the traffic of molecules and cells across the vessel wall, endothelial cells play a
central role in regulating cardiovascular functions and systemic homeostasis and in …