Emerging evidence indicates that the gut microbiota play a crucial role in the bidirectional
communication between the gut and the brain suggesting that the gut microbes may shape …

Schizophrenia is frequently a chronic and disabling disorder, characterized by
heterogeneous positive and negative symptom constellations. The objective of this review …

Importance Schizophrenia is a common, severe mental illness that most clinicians will
encounter regularly during their practice. This report provides an overview of the clinical …

The current management of patients with primary psychosis worldwide is often remarkably
stereotyped. In almost all cases an antipsychotic medication is prescribed, with second …

BackgroundDuring the last decades, a renewed interest for negative symptoms (NS) was
brought about by the increased awareness that they interfere severely with real-life …

Catatonia is a psychomotor syndrome associated with several psychiatric and medical
conditions. Psychomotor signs range from stupor to agitation, and include pathognomonic …

The negative symptoms of schizophrenia include volitional (motivational) impairment
manifesting as avolition, anhedonia, social withdrawal, and emotional disorders such as …

Negative symptoms of schizophrenia remain a major therapeutic challenge. The progress in
the conceptualization and assessment is not yet fully reflected by treatment research …

Research on negative symptoms of schizophrenia has received renewed interest since the
1980s. A scientometric analysis that objectively maps scientific knowledge, with changes in …

Background Currently approved antipsychotics do not adequately treat negative symptoms
(NS), which are a major determinant of functional disability in schizophrenia. KarXT, an M …