Lipids play crucial roles in signal transduction, contribute to the structural integrity of cellular
membranes, and regulate energy metabolism. Questions remain as to which lipid species …

The AMPK (AMP-activated protein kinase) and TOR (target-of-rapamycin) pathways are
interlinked, opposing signaling pathways involved in sensing availability of nutrients and …

Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …

Mammalian AMPK is known to be activated by falling cellular energy status, signaled by
rising AMP/ATP and ADP/ATP ratios. We review recent information about how this occurs …

AMPK is a highly conserved master regulator of metabolism, which restores energy balance
during metabolic stress both at the cellular and physiological levels. The identification of …

In eukaryotic cells AMP-activated protein kinase (AMPK) plays a major role in regulating
cellular energy balance. AMPK responds to changes in intracellular adenine nucleotide …

AMP-activated protein kinase (AMPK) is a key regulator of energy balance expressed
ubiquitously in eukaryotic cells. Here we review the canonical adenine nucleotide …

Cancer cells often have characteristic changes in metabolism. Cellular proliferation, a
common feature of all cancers, requires fatty acids for synthesis of membranes and signaling …

The AMP-activated protein kinase (AMPK) is a sensor of cellular energy and nutrient status,
expressed almost universally in eukaryotes as heterotrimeric complexes comprising catalytic …

Metabolic changes in cells that participate in inflammation, such as activated macrophages
and T-helper 17 cells, include a shift towards enhanced glucose uptake, glycolysis and …