Background Monitoring target engagement at various stages of drug development is
essential for natural product (NP)-based drug discovery and development. The cellular …

Simple Summary Cells need to produce ribosomes to sustain continuous proliferation and
expand in numbers, a feature that is even more prominent in uncontrollably proliferating …

Various agents, including drugs as well as nonmolecular stimuli, induce alterations in the
physicochemical properties of proteins in cell lysates, living cells, and organisms. These …

Mechanisms of action (MoAs) have been elusive for most antimalarial drugs in clinical use.
Decreasing responsiveness to antimalarial treatments stresses the need for a better …

The nucleoside analogue decitabine (or 5-aza-dC) is used to treat several haematological
cancers. Upon its triphosphorylation and incorporation into DNA, 5-aza-dC induces covalent …

Infants with KMT2A-rearranged B-cell acute lymphoblastic leukemia (ALL) have a dismal
prognosis. Survival outcomes have remained static in recent decades despite treatment …

Knowing that the drug candidate binds to its intended target is a vital part of drug discovery.
Thus, several labeled and label-free methods have been developed to study target …

Mechanisms-of-resistance to decitabine and 5-azacytidine, mainstay treatments for myeloid
malignancies, require investigation and countermeasures. Both are nucleoside analog pro …

Antimetabolites, in particular nucleobase and nucleoside analogues, are cytotoxic drugs
that, starting from the small field of paediatric oncology, in combination with other …

Background Sickle cell disease (SCD), a congenital hemolytic anemia that exacts terrible
global morbidity and mortality, is driven by polymerization of mutated sickle hemoglobin …