Porphyrias, is a general term for a group of metabolic diseases that are genetic in nature. In
each specific porphyria the activity of specific enzymes in the heme biosynthetic pathway is …

The advent of heme during evolution allowed organisms possessing this compound to
safely and efficiently carry out a variety of chemical reactions that otherwise were difficult or …

Recent advances in chemical proteomics have begun to characterize the reactivity and
ligandability of lysines on a global scale. Yet, only a limited diversity of aminophilic …

Microscopy and mass spectrometry (MS) are complementary techniques: The former
provides spatiotemporal information in living cells, but only for a handful of recombinant …

Tetrapyrroles like hemes, chlorophylls, and cobalamin are complex macrocycles which play
essential roles in almost all living organisms. Heme serves as prosthetic group of many …

Most iron in mammalian systems is routed to mitochondria to serve as a substrate for
ferrochelatase. Ferrochelatase inserts iron into protoporphyrin IX to form heme which is …

Porphyria diseases are a group of metabolic disorders caused by abnormal functioning of
heme biosynthesis enzymes and characterized by excessive accumulation and excretion of …

The appearance of heme, an organic ring surrounding an iron atom, in evolution forever
changed the efficiency with which organisms were able to generate energy, utilize gasses …

Heme is an integral part of proteins involved in multiple electron transport chains for energy
recovery found in almost all forms of life. Moreover, heme is a cofactor of enzymes including …

Heme plays a central role in diverse, life-essential processes that range from ubiquitous,
housekee** pathways such as respiration, to highly cell-specific ones such as oxygen …