Ferroptosis is a recently recognized cell death modality that is morphologically,
biochemically and genetically distinct from other forms of cell death and that has emerged to …

The liver is essential for metabolic homeostasis. The onset of liver cancer is often
accompanied by dysregulated liver function, leading to metabolic rearrangements …

Among more than 200 BAP1-mutant families affected by the “BAP1 cancer syndrome,”
nearly all individuals inheriting a BAP1 mutant allele developed one or more malignancies …

Background The BRCA1-associated protein-1 (BAP1) tumor predisposition syndrome (BAP1-
TPDS) is a hereditary tumor syndrome caused by germline pathogenic variants in BAP1 …

Translational control of mRNAs is a point of convergence for many oncogenic signals
through which cancer cells tune protein expression in tumorigenesis. Cancer cells rely on …

The BAP1 gene has emerged as a major tumor suppressor mutated with various
frequencies in numerous human malignancies, including uveal melanoma, malignant …

BAP1 is a ubiquitin C-terminal hydrolase domain-containing deubiquitinase with a wide
array of biological activities. Studies in which advanced sequencing technologies were used …

Mass spectrometry–based quantitative proteomics is a powerful tool for gaining insights into
function and dynamics of biological systems. However, peptides with different sequences …

Protein turnover is critical to cellular physiology as well as to the growth and maintenance of
tissues. The unique synthesis and degradation rates of each protein help to define tissue …

Carriers of heterozygous germline BAP1 mutations (BAP1+/−) develop cancer. We studied
plasma from 16 BAP1+/− individuals from 2 families carrying different germline BAP1 …