Messenger RNA-based vaccines: Past, present, and future directions in the context of the COVID-19 pandemic

S Jain, A Venkataraman, ME Wechsler… - Advanced drug delivery …, 2021 - Elsevier
Abstract mRNA vaccines have received major attention in the fight against COVID-19.
Formulations from companies such as Moderna and BioNTech/Pfizer have allowed us to …

[HTML][HTML] Nano-crosslinked dynamic hydrogels for biomedical applications

Q Wang, Y Zhang, Y Ma, M Wang, G Pan - Materials Today Bio, 2023 - Elsevier
Hydrogels resemble natural extracellular matrices and have been widely studied for
biomedical applications. Nano-crosslinked dynamic hydrogels combine the injectability and …

[HTML][HTML] Sustained delivery approaches to improving adaptive immune responses

BS Ou, OM Saouaf, J Baillet, EA Appel - Advanced Drug Delivery Reviews, 2022 - Elsevier
The immune system is one of the most important, complex biological networks regulating
and protecting human health. Its precise modulation can prevent deadly infections and fight …

Role of hydrophobic associations in self-healing hydrogels based on amphiphilic polysaccharides

M Nichifor - Polymers, 2023 - mdpi.com
Self-healing hydrogels have the ability to recover their original properties after the action of
an external stress, due to presence in their structure of reversible chemical or physical cross …

Self‐healing polymers containing nanomaterials for biomedical engineering applications: A review

MY Mollajavadi, FF Tarigheh… - Polymer …, 2023 - Wiley Online Library
Materials that can recover the function of lost or damaged parts, called self‐healing
materials, have attracted attention due to their wide usage in different fields such as water …

Nanoparticle-conjugated toll-like receptor 9 agonists improve the potency, durability, and breadth of COVID-19 vaccines

BS Ou, J Baillet, VCTM Picece, EC Gale, AE Powell… - ACS …, 2024 - ACS Publications
Development of effective vaccines for infectious diseases has been one of the most
successful global health interventions in history. Though, while ideal subunit vaccines …

Yield‐Stress and Creep Control Depot Formation and Persistence of Injectable Hydrogels Following Subcutaneous Administration

CK Jons, AK Grosskopf, J Baillet, J Yan… - Advanced Functional …, 2022 - Wiley Online Library
Hydrogels that can be injected into the body using standard needles or catheters enable a
minimally invasive strategy to prolong local delivery of therapeutic cargo. In particular …

Gelation and yielding behavior of polymer–nanoparticle hydrogels

AK Grosskopf, OA Saouaf… - Journal of Polymer …, 2021 - Wiley Online Library
Polymer–nanoparticle hydrogels are a unique class of self‐assembled, shear‐thinning, yield‐
stress fluids that have demonstrated potential utility in many impactful applications. Here, we …

[HTML][HTML] Injectable liposome-based supramolecular hydrogels for the programmable release of multiple protein drugs

S Correa, AK Grosskopf, JH Klich, HL Hernandez… - Matter, 2022 - cell.com
Directing biological functions is at the heart of next-generation biomedical initiatives in tissue
and immuno-engineering. However, the ambitious goal of engineering complex biological …

Subcutaneous delivery of an antibody against SARS-CoV-2 from a supramolecular hydrogel depot

CM Kasse, CY Anthony, AE Powell, GA Roth… - Biomaterials …, 2023 - pubs.rsc.org
Prolonged maintenance of therapeutically-relevant levels of broadly neutralizing antibodies
(bnAbs) is necessary to enable passive immunization against infectious disease …